Abstract

Early diagnosis is critical to improve outcomes in rheumatoid arthritis (RA), but current diagnostic tools have limited sensitivity. Here we report a large-scale multicenter study involving training and validation cohorts of 3,262 participants. We show that serum levels of soluble scavenger receptor-A (sSR-A) are increased in patients with RA and correlate positively with clinical and immunological features of the disease. This discriminatory capacity of sSR-A is clinically valuable and complements the diagnosis for early stage and seronegative RA. sSR-A also has 15.97% prevalence in undifferentiated arthritis patients. Furthermore, administration of SR-A accelerates the onset of experimental arthritis in mice, whereas inhibition of SR-A ameliorates the disease pathogenesis. Together, these data identify sSR-A as a potential biomarker in diagnosis of RA, and targeting SR-A might be a therapeutic strategy.

Scavenger receptor-A (SR-A) is mostly expressed by myeloid cells and has been attributed a variety of biological functions. Here the authors assess SR-A as a biomarker for diagnosis of rheumatoid arthritis (RA) using large-scale training and validation cohorts and show that modulating SR-A levels can alter progression of collagen-induced arthritis in mice.

Details

Title
Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study
Author
Hu Fanlei 1   VIAFID ORCID Logo  ; Jiang, Xiang 2 ; Guo Chunqing 3 ; Li Yingni 4 ; Chen Shixian 5 ; Zhang, Wei 6 ; Du, Yan 7 ; Wang, Ping 4 ; Zheng, Xi 2 ; Fang Xiangyu 4 ; Li, Xin 2 ; Song, Jing 2 ; Xie, Yang 4 ; Huang, Fei 4 ; Xue Jimeng 4 ; Bai Mingxin 4 ; Yuan, Jia 4 ; Liu, Xu 4 ; Ren Limin 4 ; Zhang, Xiaoying 4 ; Guo Jianping 4 ; Pan Hudan 8   VIAFID ORCID Logo  ; Yin, Su 4 ; Yi Huanfa 9 ; Ye Hua 4 ; Zuo Daming 10   VIAFID ORCID Logo  ; Li, Juan 5 ; Wu Huaxiang 7 ; Wang, Yongfu 11 ; Li, Ru 4 ; Liu, Liang 8 ; Xiang-Yang, Wang 3   VIAFID ORCID Logo  ; Li, Zhanguo 12   VIAFID ORCID Logo 

1  Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Department of Rheumatology and Immunology, Beijing, China (GRID:grid.411634.5) (ISNI:0000 0004 0632 4559); Peking University, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Beijing, China (GRID:grid.11135.37) (ISNI:0000 0001 2256 9319) 
2  Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Department of Rheumatology and Immunology, Beijing, China (GRID:grid.411634.5) (ISNI:0000 0004 0632 4559); Peking University, Peking-Tsinghua Center for Life Sciences, Beijing, China (GRID:grid.11135.37) (ISNI:0000 0001 2256 9319) 
3  Virginia Commonwealth University, School of Medicine, Department of Human & Molecular Genetics, Richmond, USA (GRID:grid.224260.0) (ISNI:0000 0004 0458 8737); Virginia Commonwealth University, School of Medicine, Institute of Molecular Medicine, Richmond, USA (GRID:grid.224260.0) (ISNI:0000 0004 0458 8737); Virginia Commonwealth University, School of Medicine, Massey Cancer Center, Richmond, USA (GRID:grid.224260.0) (ISNI:0000 0004 0458 8737) 
4  Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Department of Rheumatology and Immunology, Beijing, China (GRID:grid.411634.5) (ISNI:0000 0004 0632 4559) 
5  Southern Medical University, Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Guangzhou, China (GRID:grid.284723.8) (ISNI:0000 0000 8877 7471); Southern Medical University, Department of Rheumatology, Nanfang Hospital, Guangzhou, China (GRID:grid.284723.8) (ISNI:0000 0000 8877 7471) 
6  First Hospital Affiliated to Baotou Medical College & Inner Mongolia Key Laboratory of Autoimmunity, Department of Rheumatology and Immunology, Baotou, China (GRID:grid.284723.8) 
7  Zhejiang University School of Medicine, Department of Rheumatology, the Second Affiliated Hospital, Hangzhou, China (GRID:grid.13402.34) (ISNI:0000 0004 1759 700X) 
8  Macau University of Science and Technology, State Key Laboratory of Quality Research in Chinese Medicine, Macau, China (GRID:grid.411634.5) 
9  Virginia Commonwealth University, School of Medicine, Department of Human & Molecular Genetics, Richmond, USA (GRID:grid.224260.0) (ISNI:0000 0004 0458 8737); The First Hospital of Jilin University, Central laboratory of Eastern Division, Changchun, China (GRID:grid.430605.4) 
10  Virginia Commonwealth University, School of Medicine, Department of Human & Molecular Genetics, Richmond, USA (GRID:grid.224260.0) (ISNI:0000 0004 0458 8737); Southern Medical University, Department of Immunology, School of Basic Medical Sciences, Guangzhou, China (GRID:grid.284723.8) (ISNI:0000 0000 8877 7471) 
11  First Hospital Affiliated to Baotou Medical College & Inner Mongolia Key Laboratory of Autoimmunity, Department of Rheumatology and Immunology, Baotou, China (GRID:grid.13402.34) 
12  Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Department of Rheumatology and Immunology, Beijing, China (GRID:grid.411634.5) (ISNI:0000 0004 0632 4559); Peking University, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Beijing, China (GRID:grid.11135.37) (ISNI:0000 0001 2256 9319); Peking University, Peking-Tsinghua Center for Life Sciences, Beijing, China (GRID:grid.11135.37) (ISNI:0000 0001 2256 9319) 
Publication year
2020
Publication date
2020
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-020-15700-3
ProQuest document ID
2392416674
Copyright
© The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.