Abstract

Dear Editor: An intra-individual somatic variation (ISV) is described as the genetic difference among different tissues of the same individual. ISV increases with age, may not manifest a defined phenotype, and is associated with neurological, hematological, and immune disorders, especially with cancer.1 To analyze possible ISV in Mexican patients with colorectal cancer (CRC), we studied the polymorphism rs669 (c.2998 A>G, p.Ile1000Val) of the A2M gene, which encodes for the alpha-2 macroglobulin protein, a protease inhibitor involved in tumor progression and proliferation.2 This variant is located near a thioester site, which is necessary for the inhibitory function of the protein.

Alternate abstract:

Estimado editor:

La variación somática intraindividual (VSI) se describe como la diferencia genética entre los tejidos de un mismo individuo. La VSI se incrementa conforme avanza la edad, puede no manifestar un fenotipo definido y se asocia con alteraciones neurológicas, hematológicas e inmunes y, de manera especial, con cáncer.1

Para analizar la posible VSI en pacientes mexicanos con cáncer colorrectal (CCR), Yang et al.2 estudiaron el polimorfismo rs669 (c.2998 A>G, p.Ile1000Val) del gen A2M que codifica para la proteína alfa-2 macroglobulina, una inhibidora de proteasas involucrada en la progresión y proliferación del tumor. Esta variante se localiza cerca de un sitio tioéster, necesario para la función inhibidora de la proteína.

Details

Title
Intra-individual somatic variation of the rs669 polymorphism of the A2M gene in patients with colorectal cancer
Author
Helen Haydee Fernanda Ramírez-Plascencia  VIAFID ORCID Logo  ; Gutiérrez-Angulo, Melva  VIAFID ORCID Logo  ; Suárez-Villanueva, Alexis Sayuri  VIAFID ORCID Logo  ; Peregrina-Sandoval, Jorge  VIAFID ORCID Logo  ; María de la Luz Ayala-Madrigal  VIAFID ORCID Logo 
Pages
155-157
Section
CARTA AL EDITOR
Publication year
2020
Publication date
2020
Publisher
Universidad Nacional de Colombia
ISSN
01200011
e-ISSN
23573848
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2393026738
Copyright
© 2020. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.