Abstract

We investigated if clinical outcomes after kidney transplantation (KT) from deceased donors (DDs) with high Kidney Donor Profile Index (KDPI) can be different according to the age of KT recipients (KTRs). Six-hundred fifty-seven KTRs from 526 DDs were included from four transplant centers. We divided KTRs into elderly-KTR and young-KTR groups based on age 60 and each group was subdivided into high- or low-KDPI subgroup based on KDPI score of 65%. We compared short-term and long-term clinical outcomes among those four subgroups (low KDPI-young KTR, low KDPI-elderly-KTR, high KDPI-young-KTR, high KDPI-elderly-KTR). In short-term outcomes including acute rejection, BK virus and CMV infection, there was no significant difference among the four subgroups. In the long-term outcomes, the development of cardiovascular disease was higher in the high KDPI-elderly-KTR group than the other groups. In comparison of allograft survival rate, the high KDPI-young KTR subgroup showed highest risk for allograft failure and there was significant interaction between high-KDPI donors and young-KTR on allograft survival rate (P = 0.002). However, there was no significant difference in comparison of the patient survival rate. In conclusion, clinical impact of high-KDPI in DDs on post-transplant allograft survival may be less significant in elderly-KTR than in young-KTR.

Details

Title
Impact of Kidney Donor Profile Index Scores on Post-Transplant Clinical Outcomes Between Elderly and Young Recipients, A Multicenter Cohort Study
Author
Park, Woo Yeong 1   VIAFID ORCID Logo  ; Kim Jeong Ho 2 ; Ko Eun Jung 3 ; Ji-Won, Min 4 ; Ban, Tae Hyun 5 ; Yoon Hye-Eun 6 ; Kim Young Soo 7 ; Jin Kyubok 1 ; Yang Chul Woo 3 ; Han Seungyeup 1   VIAFID ORCID Logo  ; Chung, Byung Ha 3   VIAFID ORCID Logo 

1  Keimyung University School of Medicine, Department of Internal Medicine, Daegu, Republic of Korea (GRID:grid.412091.f) (ISNI:0000 0001 0669 3109); Keimyung University Kidney Institute, Daegu, Republic of Korea (GRID:grid.412091.f) (ISNI:0000 0001 0669 3109) 
2  The Catholic University of Korea, Division of Nephrology, Department of Internal Medicine, Daejeon St. Mary’s hospital, College of Medicine, Daejeon, Republic of Korea (GRID:grid.411947.e) (ISNI:0000 0004 0470 4224) 
3  The Catholic University of Korea, Transplant research center, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, Seoul, Republic of Korea (GRID:grid.411947.e) (ISNI:0000 0004 0470 4224); The Catholic University of Korea, Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, Seoul, Republic of Korea (GRID:grid.411947.e) (ISNI:0000 0004 0470 4224) 
4  The Catholic University of Korea, Transplant research center, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, Seoul, Republic of Korea (GRID:grid.411947.e) (ISNI:0000 0004 0470 4224); The Catholic University of Korea, Division of Nephrology, Department of Internal Medicine, Bucheon St. Mary’s hospital, College of Medicine, Bucheon, Republic of Korea (GRID:grid.411947.e) (ISNI:0000 0004 0470 4224) 
5  The Catholic University of Korea, Transplant research center, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, Seoul, Republic of Korea (GRID:grid.411947.e) (ISNI:0000 0004 0470 4224); The Catholic University of Korea, Division of Nephrology, Department of Internal Medicine, Eunpyeong St. Mary’s hospital, College of Medicine, Seoul, Republic of Korea (GRID:grid.411947.e) (ISNI:0000 0004 0470 4224) 
6  The Catholic University of Korea, Transplant research center, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, Seoul, Republic of Korea (GRID:grid.411947.e) (ISNI:0000 0004 0470 4224); The Catholic University of Korea, Division of Nephrology, Department of Internal Medicine, Incheon St. Mary’s hospital, College of Medicine, Incheon, Republic of Korea (GRID:grid.411947.e) (ISNI:0000 0004 0470 4224) 
7  The Catholic University of Korea, Transplant research center, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, Seoul, Republic of Korea (GRID:grid.411947.e) (ISNI:0000 0004 0470 4224); The Catholic University of Korea, Division of Nephrology, Department of Internal Medicine, Uijeongbu St. Mary’s hospital, College of Medicine, Uijeongbu, Republic of Korea (GRID:grid.411947.e) (ISNI:0000 0004 0470 4224) 
Publication year
2020
Publication date
2020
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-020-64055-8
ProQuest document ID
2394528825
Copyright
© The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.