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Copyright © 2020, Li et al.; licensee Beilstein-Institut. This work is published under http://creativecommons.org/licenses/by/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

A facile microwave-assisted method for the synthesis of tetramic acid derivatives has been developed through an Ugi/Dieckmann cyclization strategy with DBU. This two-step one-pot procedure afforded the targeted tetramic acid analogues in good yields. With commercially available Ugi starting materials, microwave irradiation, a simple operation, excellent yields, and a broad scope, this reaction has the potential to produce a large number of tetramic acid analogues, which cannot be easily accessed by the classic synthetic methods.

Details

Title
Microwave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction
Author
Li, Yong; Huang, Zheng; Xu, Jia; Ding, Yong; Dian-Yong, Tang; Lei Jie; Hong-yu, Li; Zhong-Zhu, Chen; Zhi-Gang, Xu
University/institution
U.S. National Institutes of Health/National Library of Medicine
Pages
663-669
Publication year
2020
Publication date
2020
Publisher
Beilstein-Institut zur Föerderung der Chemischen Wissenschaften
ISSN
2195951X
e-ISSN
18605397
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2396547219
Copyright
Copyright © 2020, Li et al.; licensee Beilstein-Institut. This work is published under http://creativecommons.org/licenses/by/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.