Content area

Abstract

With the aim of developing an effective cancer immunotherapy for common epithelial cancer, a new class of bifunctional antibody (BFA) was developed; one arm of this BFA recognized c‐erbB‐2 gene product, and the other arm recognized CD3ɛ, a T‐cell specific surface antigen. Application of this BFA with human peripheral blood lymphocytes exhibited specific anti‐tumor activity in vitro on a breast tumor cell line, ZR‐75–1, which expressed abundant c‐erbB‐2 gene product on its cell surface. These results indicate that BFA recognizing an oncogene product on cell surface is a potential new agent for cancer immunotherapy.

Details

Title
In vitro Anti‐tumor Activity of Anti‐c‐ erbB ‐2 × Anti‐CD3ɛ Bifunctional Monoclonal Antibody
Author
Sugiyama, Yoshihiro 1 ; Aihara, Miki 1 ; Shibamori, Masafumi 1 ; Deguchi, Kyohei 1 ; Imagawa, Kenichi 1 ; Kikuchi, Mikio 1 ; Momota, Hiroshi 2 ; Azuma, Takachika 3 ; Okada, Hidechika 3 ; Alper, Özge 4 ; Hitomi, Jiro 4 ; Yamaguchi, Ken 4 

1  Viral Diseases Research Division, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., 463‐10 Kagasuno, Kawaucki‐cho, Tokushima 771‐01 
2  Cell Engineering Division, Bioscience Laboratory, Earth Chemical Co., Ltd., 1122‐73 Kitamachi, Nishihama, Ako‐shi, Hyogo 678‐02 
3  Department of Molecular Biology, Nagoya City University School of Medicine, Mizuhocho, Mizuho‐ku, Nagoya 467 
4  Growth Factor Division, National Cancer Center Research Institute, Tsukiji 5‐1‐1, Chuo‐ku, Tokyo 104 
Section
RAPID COMMUNICATION
Publication year
1992
Publication date
Jun 1992
Publisher
John Wiley & Sons, Inc.
ISSN
09105050
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2400128513
Copyright
Copyright John Wiley & Sons, Inc. Jun 1992