Correction: Lifelong aerobic exercise protects against inflammaging and cancer

S9 Table is omitted from the list of Supporting Information. It can be viewed below.

Supporting information

LifeLong I Heart mRNA.

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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX

1 Plate 1 Raw CT values Average delta CT ΔCT

2 Gene ↓ Subject → S8.1 S24 S9.3 S6.4 S9.1 Y18 Y25 Y19 Y9 Gene ↓ S8.1 S24 S9.3 S6.4 S9.1 Y18 Y25 Y19 Y9 S8.1 S24 S9.3 S6.4 S9.1 Y18 Y25

3 GAPDH A 17.2227584197101 17.0960169111601 17.1450399266626 17.2261195007261 17.2124745053596 16.9728519295508 17.3746878619056 17.4504414950499 17.1233350547625 17.0068797617316 17.1670375618892 17.0066086089542 17.2249380779292 16.9480574830836 16.143782730167 16.2069201529908 16.8567610725968 16.3439680391188 GAPDH 17.159387665435098 17.185579713694352 17.0926632174552 17.41256467847775 17.06510740824705 17.0868230854217 17.0864977805064 16.1753514415789 16.6003645558578 Housekeeper GAPDH

4 IL-6 B 31.2832774422591 31.235382455168 30.2525150817788 29.9037571204569 31.6058739365401 31.9775533045845 27.9692968107875 27.9982552939548 32.7702831691699 33.7756423941107 28.2279066586806 28.0454943907626 31.386558277345 31.7741916616727 30.3798453818442 30.3087536324683 32.9874743823418 32.8994165659944 IL-6 31.25932994871355 30.07813610111785 31.791713620562298 27.983776052371148 33.2729627816403 28.136700524721597 31.58037496950885 30.34429950715625 32.9434454741681 14.099942283278452 12.892556387423497 14.699050403107098 10.571211373893398 16.20785537339325 11.049877439299898 14.49387718900245

5 IL-1b C 27.7607610399024 28.0818057660842 29.2743824258867 29.0258717700794 29.4553611635112 29.2098723094273 28.6113257800381 28.9045331522702 30.7655600970071 31.0763075351084 30.0488085335771 29.7378195063969 28.3498373549533 28.3655445868964 30.4028544981929 30.2303532089152 30.4824451280281 30.562068913743 IL-1b 27.9212834029933 29.150127097983052 29.332616736469248 28.757929466154152 30.920933816057747 29.893314019987 28.35769097092485 30.31660385355405 30.52225702088555 10.761895737558202 11.9645473842887 12.239953519014048 11.345364787676402 13.855826407810696 12.8064909345653 11.271193190418451

6 IL-18 D 31.0242427859449 30.8631544198324 30.6976407996928 29.8345660968711 30.32994861068 30.3145546343817 27.7622969217847 27.6972954924814 30.5621005433449 30.718048359783 29.7132291328988 29.8871056810122 30.4645477381786 30.5593651611927 29.1422958771514 29.0787128186274 31.8903661393288 32.0048169676586 IL-18 30.943698602888652 30.26610344828195 30.32225162253085 27.72979620713305 30.64007445156395 29.800167406955502 30.51195644968565 29.110504347889403 31.9475915534937 13.784310937453554 13.080523734587597 13.22958840507565 10.317231528655299 13.5749670433169 12.713344321533803 13.42545866917925

7 NFKb-1 E 24.8254567305921 25.1348088185582 25.0062082930937 24.5186512654426 24.8872569734572 24.779394225765 24.1319627569722 24.0011813531246 24.4887046419295 24.6995725596868 24.3820148457641 24.3865172414558 24.5644210615383 24.6691290358862 24.2274232660528 24.0889242450612 25.0731850378707 24.6953365937736 NFKb-1 24.98013277457515 24.76242977926815 24.8333255996111 24.0665720550484 24.59413860080815 24.384266043609948 24.61677504871225 24.158173755557 24.884260815822152 7.820745109140052 7.576850065573797 7.7406623821559 6.65400737657065 7.529031192561099 7.297442958188249 7.53027726820585

8 NFkb-2 F 26.7045516920118 26.6757345804755 26.7646421207714 26.8003272797153 26.6759706329691 27.0759950868447 25.8618089955849 26.1801295324672 27.1202851729312 27.0835233764581 26.2010221629559 26.2986877952507 26.3336393871413 26.4945753531329 25.7828308451832 25.9383731474701 27.3708254452238 26.9787996700945 NFkb-2 26.69014313624365 26.78248470024335 26.875982859906898 26.02096926402605 27.10190427469465 26.2498549791033 26.4141073701371 25.86060199632665 27.174812557659152 9.53075547080855 9.596904986549 9.783319642451698 8.6084045855483 10.036796866447599 9.163031893681602 9.3276095896307

9 Cdkn1a G 24.5507361616066 25.3559147556468 24.6079147431688 25.1782502986826 25.2563040633391 25.1598136456992 24.4294896036426 24.5228059376776 26.4031158122344 26.1242908123156 24.5802551734152 24.6413624043314 24.4282269326323 24.1965984515812 25.2088295538285 25.0528520694569 25.3329599581332 24.8160728889468 Cdkn1a 24.9533254586267 24.8930825209257 25.20805885451915 24.4761477706601 26.263703312275 24.6108087888733 24.312412692106747 25.1308408116427 25.074516423539997 7.793937793191603 7.7075028072313465 8.115395637063951 7.063583092182348 9.198595904027947 7.523985703451601 7.2259149116003485

10 CDKn2a H 31.4164200969947 31.0429903524676 31.2079072243556 31.4143918034498 31.934769607 32.5200067014273 30.9810559840924 31.187906600095 31.5622914271198 31.6594025383255 33.7404204593239 33.0560980126742 33.3737262937795 33.5228506413887 32.6502542170308 33.0616429880405 34.722677748124 35.0908853816313 CDKn2a 31.22970522473115 31.3111495139027 32.22738815421365 31.0844812920937 31.61084698272265 33.39825923599905 33.4482884675841 32.85594860253565 34.90678156487765 14.07031755929605 14.125569800208346 15.134724936758449 13.671916613615949 14.545739574475597 16.31143615057735 16.3617906870777

11 CXCL1 I 28.7206322985985 28.9339128995328 28.3298871415528 28.0462166079446 29.1076582245152 29.2643337952645 29.6820397705059 29.3485383661744 29.6849346064857 29.9287287583586 29.3483864108378 29.3275096675003 29.0009619306224 29.3668816551351 29.2808715089445 29.327670178107 30.649263415718 30.4691555624855 CXCL1 28.82727259906565 28.1880518747487 29.18599600988985 29.51528906834015 29.80683168242215 29.33794803916905 29.18392179287875 29.30427084352575 30.55920948910175 11.667884933630553 11.00247216105435 12.093332792434648 12.102724389862399 12.741724274175098 12.25112495374735 12.09742401237235

12 Stat3 J 26.0904890379949 25.9328304379032 25.9063931310091 26.1329342458923 26.4609068410479 26.4297398050048 25.7018593565636 24.9656464528592 26.0560010797303 25.8896903923348 25.1840850843387 25.3433284943611 25.7927734157918 25.6862456816375 24.7283906358084 25.0138247366201 26.1147216604091 25.8976191416658 Stat3 26.01165973794905 26.0196636884507 26.44532332302635 25.3337529047114 25.97284573603255 25.2637067893499 25.73950954871465 24.871107686214252 26.00617040103745 8.852272072513951 8.834083974756346 9.35266010557115 7.9211882262336495 8.907738327785498 8.176883703928201 8.653011768208252

13 TNF-a K 30.1073341921065 30.5360636345848 30.2260615221732 29.9559067650374 29.2464199480057 29.1643666740457 28.6089768107746 28.79978930134 29.6793392945751 29.1310263213341 29.9822045453806 29.6659316486985 30.7461596433001 30.2097075953468 29.6386111561683 29.709346427943 30.1151871528581 29.8693295774509 TNF-a 30.32169891334565 30.0909841436053 29.2053933110257 28.7043830560573 29.405182807954603 29.82406809703955 30.47793361932345 29.67397879205565 29.9922583651545 13.162311247910552 12.905404429910948 12.112730093570498 11.291818377579549 12.340075399707551 12.737245011617851 13.391435838817053

14 Casp1 L 27.2033919131097 27.6744363531269 26.5802828002749 26.2281642714393 26.4250342743884 26.7102082676285 25.6336464042801 25.5547383413519 27.0678362649028 27.0065083778922 27.2463448661041 27.1608443954414 27.35798527279 27.3796265798296 26.627225712546 26.8875428314112 27.5112526099685 27.5986345348855 Casp1 27.438914133118303 26.4042235358571 26.56762127100845 25.594192372816 27.0371723213975 27.20359463077275 27.3688059263098 26.7573842719786 27.554943572427 10.279526467683205 9.218643822162747 9.474958053553248 8.18162769433825 9.972064913150447 10.11677154535105 10.282308145803402

15 NEK7 M 23.9685847278823 24.5433164196844 23.43572321289 23.9081916995917 23.5086828809897 23.5270279353252 23.2133882975186 23.2757457924196 23.3805267633634 23.5192038087196 23.1886907682083 23.4814557673291 23.358820269235 24.1215698673907 22.9541524276427 22.8534133014146 23.7893714938226 23.5573365389361 NEK7 24.25595057378335 23.67195745624085 23.517855408157452 23.2445670449691 23.4498652860415 23.3350732677687 23.74019506831285 22.90378286452865 23.67335401637935 7.09656290834825 6.486377742546498 6.425192190702251 5.8320023664913485 6.384757877794449 6.248250182347 6.653697287806452

16 NLRP3 N 30.244118458751 29.5369897211229 30.3603582591055 30.2503268831856 29.4758591262319 29.4736269640112 29.3352875367771 29.320653238761 30.26 30.1814655814764 31.146281441585 30.6535936006003 29.45 29.6706759432538 29.7277413856785 29.6453588719767 32.0548305999839 31.4854419974249 NLRP3 29.89055408993695 30.30534257114555 29.47474304512155 29.32797038776905 30.2207327907382 30.89993752109265 29.5603379716269 29.686550128827598 31.7701362987044 12.73116642450185 13.1197628574512 12.382079827666349 11.9154057092913 13.155625382491149 13.81311443567095 12.473840191120502

17 ASC O 26.9861347390865 27.0521925568865 27.534747032205 26.6997139959596 27.0828035675481 27.0235988480711 25.8575043892974 26.0087951630763 26.696034618544 27.1135738040462 26.1538464899565 26.0982055323081 26.9292364798881 26.7892820090882 25.841950717191 25.4027055290128 27.1753237657249 27.1722998114956 ASC 27.0191636479865 27.1172305140823 27.0532012078096 25.933149776186852 26.9048042112951 26.1260260111323 26.85925924448815 25.6223281231019 27.17381178861025 9.859775982551401 9.93165080038795 9.9605379903544 8.520585097709102 9.83969680304805 9.039202925710601 9.772761463981752

18 SPARC P 22.4062672259926 22.5213462994263 22.1406264428644 22.1952706102821 22.3852686414166 23.3004426221895 20.7103936770761 21.0545135691509 22.0901620956444 22.4793107093598 22.6866619438751 21.6821678981581 22.3 21.6934115711809 21.0815559489363 21.0559757672406 22.1297187073265 21.8817057286147 SPARC 22.46380676270945 22.167948526573248 22.84285563180305 20.8824536231135 22.284736402502098 22.1844149210166 21.99670578559045 21.068765858088447 22.0057122179706 5.3044190972743515 4.982368812878896 5.7501924143478504 3.4698889446357484 5.2196289942550465 5.097591835594901 4.910208005084051

19 Raw CT values

20

21 Plate 2 Raw CT values Average delta CT ΔCT

22 Gene ↓ Subject → Y29 Y20 Y28 Y30 S16 S14 S12 S10.3 V13 V11 V14 V46 Gene ↓ Y29 Y20 Y28 Y30 S16 S14 S12 S103 V13 V11 V14 V46 Y29 Y20 Y28 Y30 S16 S14 S12

23 GAPDH A 16.293560743969 16.1417067208684 16.2600036761297 16.3113605800391 17.010978758705 16.7209601108189 16.5686201611232 16.8851996102611 17.4137682040216 17.242127171319 16.9767268817679 17.0483719969761 17.4241919893072 17.299333971556 16.4599845722071 16.5771703316766 16.8455476895615 16.4501449293555 16.8819805983714 16.6896656447133 16.7390464896422 16.5684558668223 16.6615951406149 16.4792856375288 GAPDH 16.217633732418697 16.2856821280844 16.86596943476195 16.72690988569215 17.327947687670303 17.012549439372002 17.3617629804316 16.51857745194185 16.6478463094585 16.78582312154235 16.65375117823225 16.570440389071848 Housekeeper GAPDH

24 IL-6 B 31.9779855493765 32.1849790659976 31.0504961031397 31.1235565280428 29.9318906421218 30.0235128874279 32.5807258768207 32.6716321882297 29.7924657423067 30.3822967637349 30.2832675319554 30.5253363870767 30.551736703068 30.5645885874489 30.1297070252371 30.3064991628566 31.6342338432437 31.5546143386919 29.1098824445721 29.0403083276471 31.3009519696173 31.0187709481618 30.596096160505 30.7028923737296 IL-6 32.081482307687054 31.087026315591253 29.97770176477485 32.6261790325252 30.0873812530208 30.404301959516047 30.55816264525845 30.21810309404685 31.5944240909678 29.075095386109602 31.15986145888955 30.649494267117298 15.863848575268356 14.801344187506853 13.111732330012899 15.89926914683305 12.759433565350498 13.391752520144045 13.19639966482685

25 IL-1b C 31.4110533353836 31.3403097095696 28.3003454602632 28.6204535552867 27.658820566678 27.5503153915688 31.7712095185538 31.6715032300222 28.5698324946154 28.7582775432937 30.0265342382853 30.3823535573399 28.4442324554345 28.4168782811412 28.1419915275117 28.1978214031064 30.4255977662948 30.5628585216519 27.9208339941263 28.0454284934308 28.4044753310727 28.8790844669792 29.1823427338666 29.2371826736391 IL-1b 31.375681522476597 28.46039950777495 27.604567979123402 31.721356374288 28.66405501895455 30.204443897812602 28.43055536828785 28.169906465309047 30.494228143973352 27.98313124377855 28.64177989902595 29.20976270375285 15.1580477900579 12.174717379690552 10.738598544361452 14.994446488595848 11.336107331284246 13.1918944584406 11.068792387856249

26 IL-18 D 30.31055808673 30.478246512712 30.9993022781267 30.2306141150311 30.9405265880019 30.1442921738472 30.7361343399688 30.5954126287681 28.3689673513654 28.5152642975954 29.319750474891 29.2375734708123 30.4094273865711 30.365827037434 30.0200544219788 29.9778066744347 29.9783527847161 29.810511797824 29.4313348532182 29.5089015732421 30.0989858283268 29.5090034298583 29.3019654337087 30.0366068038679 IL-18 30.394402299721 30.614958196578897 30.542409380924553 30.66577348436845 28.4421158244804 29.27866197285165 30.38762721200255 29.99893054820675 29.89443229127005 29.47011821323015 29.80399462909255 29.6692861187883 14.176768567302304 14.329276068494497 13.676439946162603 13.9388635986763 11.114168136810097 12.26611253347965 13.02586423157095

27 CDKn2a H 33.3536079563764 33.2837073070103 33.2821894988455 33.5313635011268 32.0031719154417 32.1264214362614 33.027847782411 33.0652289550502 30.4591305340918 30.1018891209831 30.6518294499799 30.4272342796714 32.5570894361143 31.9730028600222 31.2548548948175 31.3745576754156 32.1558076647358 32.34 30.4256999716845 30.7164246002285 30.7579272404818 30.3964626151734 31.3898296238309 30.9782835326923 CDKn2a 33.318657631693355 33.40677649998615 32.064796675851554 33.0465383687306 30.28050982753745 30.539531864825648 32.26504614806825 31.31470628511655 32.2479038323679 30.5710622859565 30.5771949278276 31.184056578261597 17.101023899274658 17.12109437190175 15.198827241089603 16.31962848303845 12.952562139867148 13.526982425453646 14.903283167636651

28 TNF-a K 29.985845282267 30.1914727828687 30.0087025832146 30.1953471452506 30.1331443602785 30.032262698709 29.1242166514741 29.6781015634508 29.6479903410576 29.6105462841146 28.9059088102153 28.7696908821938 28.3265906540304 28.6572053840572 28.7641114477799 29.1300373639615 29.4981935723485 29.4297439379849 29.296080631016 29.410838848631 29.2399400942671 29.0537571118476 29.9145984224415 29.7935132958975 TNF-a 30.08865903256785 30.1020248642326 30.08270352949375 29.401159107462448 29.6292683125861 28.83779984620455 28.491898019043802 28.9470744058707 29.4639687551667 29.3534597398235 29.14684860305735 29.8540558591695 13.871025300149153 13.8163427361482 13.216734094731798 12.674249221770296 12.301320624915796 11.825250406832549 11.130135038612202

29 NLRP3 N 31.7813028892092 31.1739815382688 30.8174032661895 30.943170873027 29.315172954405 29.2812563745593 30.7349114684984 31.6766473912764 30.3419876987925 30.8186789190664 30.7595624103958 30.7562617332753 31.0490793605241 30.819634694404 30.8791534415438 31.2446210345133 31.067064906161 31.0217646549406 30.3773614308648 30.3347042439429 29.9669914617676 30.011149556504 30.5366616416394 30.7612937461676 NLRP3 31.477642213739003 30.88028706960825 29.298214664482153 31.2057794298874 30.58033330892945 30.75791207183555 30.934357027464053 31.06188723802855 31.044414780550802 30.356032837403852 29.9890705091358 30.6489776939035 15.260008481320305 14.594604941523851 12.432245229720202 14.478869544195248 13.252385621259148 13.745362632463547 13.572594047032453

30 Raw CT values

31

32 Plate 3 Raw CT values Average delta CT ΔCT

33 Gene ↓ Subject → Y10 Y36 Y35 Y17 Y6 Y27 Y26 S9.2 V21 V45 V16 V44 Gene ↓ Y10 Y36 Y35 Y17 Y6 Y27 Y26 S9.2 V21 V45 V16 V44 Y10 Y36 Y35 Y17 Y6 Y27 Y26

34 GAPDH A 16.6427485131115 16.6312665777668 16.6083534234443 16.7204027504262 16.8779430050415 17.004037870013 17.0017381448826 17.2765854180265 16.9084899257898 16.5588209370634 17.0761090181298 18.0741570747706 16.7878157840707 17.0904929980519 16.7792660013395 16.6541754430292 16.4341873386612 16.2536277730287 16.8507271650364 16.5128761067568 16.9661301828548 16.7837632445211 16.7268766468938 16.6966986554892 GAPDH 16.63700754543915 16.66437808693525 16.94099043752725 17.13916178145455 16.733655431426598 17.575133046450198 16.9391543910613 16.71672072218435 16.34390755584495 16.681801635896598 16.87494671368795 16.7117876511915 Housekeeper GAPDH

35 IL-6 B 32.4625170507928 32.2695350014557 33.0600156738274 32.6043266341105 33.1210301091388 32.806434107934 30.7750334573086 31.0853247940332 33.1547243470125 33.8626246535141 28.3432150273301 28.1930726856352 30.1800552005795 30.4360289366224 29.740678688162 29.9291614646262 32.3048726557679 31.7344893282062 30.0189630046953 29.6559762148652 31.0348190782056 30.9091635977452 31.9118935008103 31.930896749368 IL-6 32.366026026124246 32.83217115396895 32.963732108536405 30.930179125670897 33.5086745002633 28.268143856482652 30.308042068600948 29.8349200763941 32.01968099198705 29.83746960978025 30.9719913379754 31.92139512508915 15.729018480685095 16.1677930670337 16.022741671009154 13.791017344216346 16.7750190688367 10.693010810032455 13.368887677539647

36 IL-1b C 30.4682401011915 31.0521793668257 30.5874753128928 31.1396448371052 31.8372285723263 31.5505612333966 29.9676623603575 30.1542225075255 30.366035490686 30.2949383530687 27.5865324773774 27.4006347342222 28.0478272673388 28.1758417292114 26.2953862906791 26.2012052395648 30.5513437852063 30.8393686977106 28.0923792279265 27.9391707015828 28.5280213319516 28.5136418717031 30.7257208843941 30.6581596733468 IL-1b 30.7602097340086 30.863560074999 31.69389490286145 30.0609424339415 30.330486921877352 27.4935836057998 28.1118344982751 26.248295765121952 30.695356241458448 28.015774964754648 28.52083160182735 30.691940278870447 14.12320218856945 14.19918198806375 14.7529044653342 12.921780652486948 13.596831490450754 9.918450559349601 11.1726801072138

37 IL-18 D 30.8004162343817 30.7286343923845 31.1280030958407 30.5706968676044 30.4820715436128 30.4278736291139 29.3384561966475 29.0712065949843 30.7656284800341 30.7474336393598 30.8973538796905 30.6696074031789 30.0586529032171 30.0890284122355 28.6855182637236 28.6895212213708 29.7219056086042 29.9597474673489 30.2822715046709 30.1275363889369 30.1353181102527 30.0459591172612 30.2912628982385 30.2600048205061 IL-18 30.7645253133831 30.84934998172255 30.45497258636335 29.2048313958159 30.75653105969695 30.7834806414347 30.0738406577263 28.687519742547202 29.84082653797655 30.2049039468039 30.09063861375695 30.2756338593723 14.12751776794395 14.1849718947873 13.5139821488361 12.06566961436135 14.022875628270352 13.208347594984502 13.134686266665

38 CDKn2a H 33.524239558187 33.1487165251275 32.3179330052434 32.2677379594287 33.2022334837474 33.5504171363145 30.4433577384468 30.8765684797734 33.5421546698513 33.9633235035938 33.1968770317995 33.4788385344656 33.1980132483674 33.0512545626595 30.7154637079564 30.8211358249813 31.1287492241576 31.0363769745388 31.8949904860947 31.4440423644778 31.5812480893507 31.197034262796 31.6623860536885 31.4664458246499 CDKn2a 33.336478041657244 32.292835482336045 33.37632531003095 30.6599631091101 33.75273908672255 33.33785778313255 33.12463390551345 30.76829976646885 31.0825630993482 31.669516425286247 31.389141176073352 31.5644159391692 16.699470496218094 15.628457395400794 16.4353348725037 13.520801327655551 17.01908365529595 15.762724736682351 16.185479514452147

39 TNF-a K 30.6493191274013 30.6917055900176 30.3325002105791 30.7324343467147 29.8836871846258 29.7341521750465 29.5352181232935 29.114951773091 31.5815726518099 31.2553487811256 29.6947087279032 29.7725310558448 30.3487911865326 30.2302723899279 29.4624105254438 29.6677329606514 29.0803256400222 28.9115541840629 29.7730894114362 29.5458892515982 29.4162117089128 29.534706009782 29.1555369751485 29.5942886746896 TNF-a 30.670512358709452 30.532467278646898 29.80891967983615 29.32508494819225 31.41846071646775 29.733619891874 30.28953178823025 29.5650717430476 28.99593991204255 29.6594893315172 29.4754588593474 29.37491282491905 14.033504813270302 13.868089191711647 12.8679292423089 12.185923166737698 14.68480528504115 12.158486845423802 13.350377397168948

40 NLRP3 N 31.2149840286425 30.6584135570448 29.5862078362655 29.5573901722739 30.8462781225482 30.9702056848495 31.3351795930717 31.0061924302478 29.6097952272591 29.458607666479 30.7077801987228 30.4616272323748 29.1381122845042 29.078344654212 29.2317731502272 29.2995490275868 30.0898096859153 29.9811355212467 31.5359138278419 30.808769208835 30.8619153589729 30.7268272956943 31.2814096711341 31.350831206322 NLRP3 30.93669879284365 29.5717990042697 30.90824190369885 31.17068601165975 29.534201446869048 30.584703715548798 29.1082284693581 29.265661088907 30.035472603581 31.17234151833845 30.7943713273336 31.31612043872805 14.2996912474045 12.907420917334449 13.9672514661716 14.0315242302052 12.80054601544245 13.0095706690986 12.169074078296799

41 Raw CT values

42

43 Plate 4 Raw CT values Average delta CT ΔCT

44 Gene ↓ Subject → V12 V17 V43 Y5 S8.2 S13 S25 S10.1 V23 V47 V48 V49 Gene ↓ V12 V17 V43 Y5 S8.2 S13 S25 S10.1 V23 V47 V48 V49 V12 V17 V43 Y5 S8.2 S13 S25

45 GAPDH A 17.1618918495174 16.7612127913929 16.9416376515294 16.9137909838387 16.9848158778488 17.0284966634989 16.9187709672707 16.9635267854026 16.7162075872235 16.5392858022413 17.1319201134275 16.7826790791008 16.5021561825669 16.4526288217153 16.1773075322142 16.4585450705004 16.5015508454732 16.4328275386692 17.172268140934 17.0250955777248 16.8973870822789 16.5073212114593 17.0239395141232 16.9705617293554 GAPDH 16.961552320455148 16.92771431768405 17.00665627067385 16.941148876336648 16.6277466947324 16.95729959626415 16.4773925021411 16.3179263013573 16.467189192071203 17.098681859329403 16.702354146869098 16.997250621739298 Housekeeper GAPDH

46 IL-6 B 29.7335478515619 29.5824951177067 30.7177446720726 30.8437240072487 32.1244053880169 32.0741917703567 31.9014978969055 32.1271269807697 30.3627472473449 31.4421457880585 31.3263842086104 30.9467606364878 28.1270810339471 28.4641695890613 30.7755133855398 31.054667873876 31.4324644051741 31.5969828356367 31.0427757600042 30.5562247904195 31.0691403336512 30.6624420982644 30.4151724273143 30.7866635329212 IL-6 29.6580214846343 30.78073433966065 32.0992985791868 32.0143124388376 30.902446517701698 31.1365724225491 28.2956253115042 30.915090629707898 31.514723620405398 30.799500275211848 30.8657912159578 30.60091798011775 12.696469164179153 13.8530200219766 15.09264230851295 15.073163562500952 14.274699822969296 14.17927282628495 11.8182328093631

47 IL-1b C 29.5420011302596 29.3649878524837 29.084689621586 29.1965506600856 30.6594554311857 30.540584809016 28.714427599898 28.7387564362487 28.3783034904721 28.3763752148699 29.4884963313329 29.0233631448736 28.3073004831545 28.3753030251852 29.3686928351699 29.1628361427495 28.5573902080375 28.5139901124428 29.3341362724383 29.6368110532973 28.7909300074321 28.792250098431 28.1036276010706 28.4276776220468 IL-1b 29.45349449137165 29.1406201408358 30.60002012010085 28.726592018073347 28.377339352671 29.255929738103248 28.341301754169848 29.2657644889597 28.53569016024015 29.4854736628678 28.79159005293155 28.2656526115587 12.491942170916502 12.21290582315175 13.593363849427 11.7854431417367 11.7495926579386 12.298630141839098 11.863909252028748

48 IL-18 D 29.9067554470712 29.2041912198301 30.5555455152914 30.1106269805751 30.4703403577728 30.3769224827548 30.6024782071412 30.5874261603684 28.7639594712661 29.1068173743241 30.7060548511081 30.5012639185155 29.4531515780965 29.4847460199832 29.3806139317678 29.4359286345558 30.3718958722216 30.6103404744565 30.7328470074894 30.7744646509905 30.5563067969235 30.6267706035428 30.0935273032205 30.054288955919 IL-18 29.55547333345065 30.33308624793325 30.4236314202638 30.5949521837548 28.9353884227951 30.6036593848118 29.46894879903985 29.408271283161803 30.49111817333905 30.75365582923995 30.59153870023315 30.07390812956975 12.593921012995501 13.4053719302492 13.416975149589948 13.653803307418151 12.307641728062698 13.646359788547649 12.99155629689875

49 CDKn2a H 31.0081116029292 30.8872386224636 33.2951560313212 33.4545395273154 31.5263809455869 31.7584508779642 33.1481007400142 34.0230526266682 31.2407862047594 31.4243652976295 31.7323751785591 31.4343685717408 30.2803536134235 30.6661300188166 30.1983903898067 30.6871985696482 31.113028697754 31.2431760161162 32.2241662781722 31.6526532118345 31.3794092150591 31.0866698614429 31.5189023042937 31.3861487947171 CDKn2a 30.947675112696402 33.3748477793183 31.64241591177555 33.5855766833412 31.332575751194447 31.58337187514995 30.47324181612005 30.44279447972745 31.1781023569351 31.938409745003348 31.233039538251 31.452525549505403 13.986122792241254 16.44713346163425 14.6357596411017 16.644427807004554 14.704829056462046 14.6260722788858 13.995849313978951

50 TNF-a K 30.3404071334314 30.5054443315553 30.8697195480183 31.0409180711798 29.3985012169684 29.5883562162907 30.5590186309584 30.7981765723326 29.9499676349377 29.49802653749 29.2927272196698 29.3535892279318 29.1756333238329 29.1038331864059 28.8816711683147 29.213299886725 30.2731747964397 30.1639598128072 30.5479061078705 30.0838625722847 29.8929630408409 29.7948638318941 30.0113752484281 29.5876864244339 TNF-a 30.422925732493347 30.95531880959905 29.49342871662955 30.6785976016455 29.72399708621385 29.3231582238008 29.139733255119403 29.04748552751985 30.21856730462345 30.315884340077602 29.8439134363675 29.799530836431 13.4613734120382 14.027604491915 12.486772445955697 13.737448725308852 13.096250391481448 12.36585862753665 12.662340752978302

Raw CT mRNA dataHousekeeper Verification

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LifeLong I Heart mRNA.

Raw CT mRNA data.

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S9 Table. LifeLong I Heart mRNA.

Raw CT mRNA data.

https://doi.org/10.1371/journal.pone.0233401.s001

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References

1. Nilsson MI, Bourgeois JM, Nederveen JP, Leite MR, Hettinga BP, Bujak AL, et al. (2019) Lifelong aerobic exercise protects against inflammaging and cancer. PLoS ONE 14(1): e0210863. https://doi.org/10.1371/journal.pone.0210863 pmid:30682077