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Abstract
Lipids stored in skeletal muscle cells are known as intramyocellular lipid (IMCL). Disorders involving IMCL and its causative factor, circulatory free fatty acids (FFAs), induce a toxic state and ultimately result in insulin resistance (IR) in muscle tissue. On the other hand, intramuscular triglyceride (IMTG), the most abundant component of IMCL and an essential energy source for active skeletal muscle, is different from other IMCLs, as it is stored in lipid droplets and plays a pivotal role in skeletal muscle energy homeostasis. This review discusses the association of FFA-induced ectopic lipid accumulation and IR, with specific emphasis on the relationship between IMCL/IMTG metabolism and IR.
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1 Beihang University, Department of Biological Science and Biotechnology, School of Biological Science and Medical Engineering, Beijing, China (GRID:grid.64939.31) (ISNI:0000000099991211); Chinese Academy of Sciences, National Laboratory of Biomacromolecules, Institute of Biophysics, Beijing, China (GRID:grid.9227.e) (ISNI:0000000119573309)
2 Chinese Academy of Sciences, National Laboratory of Biomacromolecules, Institute of Biophysics, Beijing, China (GRID:grid.9227.e) (ISNI:0000000119573309); University of Chinese Academy of Sciences, Beijing, China (GRID:grid.410726.6) (ISNI:0000000417978419)
3 Capital University of Physical Education and Sport, Beijing, China (GRID:grid.440659.a)
4 Beihang University, Department of Biological Science and Biotechnology, School of Biological Science and Medical Engineering, Beijing, China (GRID:grid.64939.31) (ISNI:0000000099991211)
5 La Trobe University, School of Life Sciences, Melbourne, Australia (GRID:grid.1018.8) (ISNI:0000000123420938)