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Copyright © 2013 D. C. Damasceno et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The presence of diabetes in pregnancy leads to hormonal and metabolic changes making inappropriate intrauterine environment, favoring the onset of maternal and fetal complications. Human studies that explore mechanisms responsible for changes caused by diabetes are limited not only for ethical reasons but also by the many uncontrollable variables. Thus, there is a need to develop appropriate experimental models. The diabetes induced in laboratory animals can be performed by different methods depending on dose, route of administration, and the strain and age of animal used. Many of these studies are carried out in neonatal period or during pregnancy, but the results presented are controversial. So this paper, addresses the review about the different models of mild diabetes induction using streptozotocin in pregnant rats and their repercussions on the maternal and fetal organisms to propose an adequate model for each approached issue.

Details

Title
Mild Diabetes Models and Their Maternal-Fetal Repercussions
Author
Damasceno, D C 1 ; Sinzato, Y K 1 ; Bueno, A 1 ; Netto, A O 1 ; Dallaqua, B 1 ; Gallego, F Q 1 ; Iessi, I L 1 ; Corvino, S B 1 ; Serrano, R G 1 ; Marini, G 1 ; Piculo, F 1 ; Calderon, I M P 1 ; Rudge, M V C 1 

 Laboratory of Experimental Research on Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP, Brazil 
Editor
Daisuke Koya
Publication year
2013
Publication date
2013
Publisher
John Wiley & Sons, Inc.
ISSN
23146745
e-ISSN
23146753
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2407631938
Copyright
Copyright © 2013 D. C. Damasceno et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.