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Copyright © 2020 Lu-Lu Qin et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background. Emerging studies have explored the association between the famine exposure during early life and the risk of the metabolic syndrome, and the results remain controversial. This meta-analysis was performed to summarize the famine effects on the prevalence of metabolic syndrome (MetS) in adulthood. Materials and Methods. We searched the PubMed, Web of Science, Embase, ScienceDirect, and Chinese National Knowledge Infrastructure for relevant studies up to December 2019. Pooled odd ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the effect exposure to famine on MetS using a random-effects model, and the I2 was used to evaluate the heterogeneity. Results. The analyses included 39 studies from 10 articles with a total of 81504 participants. Fourteen studies from 10 articles for fetal famine exposure, 20 studies from 7 articles for childhood famine exposure, and 5 studies from 3 articles for adolescence/adult famine exposure were included in this meta-analysis. Compared with a nonexposed group, famine exposure significantly increased the risk of MetS for early life famine exposure (OR=1.27, 95% CI: 1.18-1.38), fetal famine exposure (OR=1.27, 95% CI: 1.14-1.43), and childhood famine exposure (OR=1.29, 95% CI: 1.16-1.44). Subgroup analyses showed that the result was consistent regardless of the study designs, definitions of MetS, and causes of famine, with or without adjustment for age, smoking, drinking, and physical activity. Conclusions. This meta-analysis suggests that exposure to famine during early life may increase the risk of MetS in adulthood.

Details

Title
Effect of Exposure to Famine during Early Life on Risk of Metabolic Syndrome in Adulthood: A Meta-Analysis
Author
Lu-Lu, Qin 1   VIAFID ORCID Logo  ; Bang-An, Luo 2 ; Gao, Fan 3   VIAFID ORCID Logo  ; Xiang-Lin, Feng 4 ; Jia-He, Liu 4 

 Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410081, China; Department of Social Medicine and Health Management, School of Medicine, Hunan Normal University, Changsha 410081, China 
 Department of Mental Health, Brain Hospital of Hunan Province, Changsha, 410007 Hunan, China 
 Department of Health Monitoring, Xi’an Center for Disease Control And Prevention, Xi’an, Shaanxi 710054, China 
 Department of Social Medicine and Health Management, School of Medicine, Hunan Normal University, Changsha 410081, China 
Editor
Andrea Tura
Publication year
2020
Publication date
2020
Publisher
John Wiley & Sons, Inc.
ISSN
23146745
e-ISSN
23146753
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2407642604
Copyright
Copyright © 2020 Lu-Lu Qin et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.