Erratum to “DNMT3A Mutations in Patients with Acute Myeloid Leukemia in South Brazil”

Abstract

Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Patient identification Mutation Allelic change Exon Type of mutation FAB subtype PCR Risk group Karyotype 39 D748N G > A 19 Missense M1 Negative Intermediate Normal 79 R882H G > A 23 Missense M1 Negative Intermediate Trisomy (8)(9) 4 R882H G > A 23 Missense M3 Negative Intermediate Normal 70 R882H G > A 23 Missense M2 Negative Intermediate Normal 41 P896* A > G 23 Silent M3 PML/RARα Favorable t(15;17) Table 5 Clinical characteristics of patients with Acute Myeloid Leukemia with or without DNMT3A mutations. Characteristics Number of pts (%) DNMT3A mutated Number of pts (%) DNMT3A not mutated P Age (median) 47.4 40.4 0.42 Sex        Male 60%  ( 3 ) 57.9% ( 44 ) 0.92  Female 40% ( 2 ) 42.1% ( 32 ) Subtype FAB        M0 0% 7.2%   ( 5 )    M1 60%   ( 3 ) 18.8%   ( 13 )    M2 20%   ( 1 ) 30.4%   ( 21 ) 0.56  M3 20%   ( 1 ) 20.3%   ( 14 )  M4 0% 18.8%   ( 13 )    M5 0% 1.4%   ( 1 )    Not M3 0% 2.9%   ( 2 )   Risk groups        Favorable 20%   ( 1 ) 29.8%   ( 17 )    Intermediate 80%   ( 4 ) 59.6%   ( 34 ) 1.000  Unfavorable 0% 10.5%   ( 6 )   Leukocytes (×103) (median) 20.67 6.41 0.28 Death 40% ( 2 ) 52.7% ( 39 ) 0.66 Relapses 40% ( 2 ) 29.2% ( 21 ) 0.63 Refractory 20%   ( 1 ) 19.1%   ( 13 ) 0.96 [figure omitted; refer to PDF]

This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

The purpose of this note is to correct both the analysis and typographical errors.

The typos are as follows.

 

The abstract, line 6: In “in 6 patients (8%)” should read “in 5 patients (6%)”.

 

Page 4, line 12: In “8% (6) of the samples, being 5 missens” should read “6% (5) of the samples, being 4 missense”.

 

Page 4, line 19: In “Of the 6 cases” should read “Of the 5 cases”.

 

Page 4, line 20: In “(5, or 83.3%)” should read “(4, or 80%)”.

 

Page 4, second column, line 8: In “OS for patients with wild DNMT3A gene was 41.4% and for patients with mutated DNMT3A was 44.4% ( $P=0.59$ )” should read “OS for patients with wild DNMT3A gene was 45.7% and for patients with mutated DNMT3A was 60.0% ( $P=0.47$ )”.

 

Page 6, line 4: In “found in 8%” should read “found in 6%”.

 

Page 6, second column, line 13: In “3 of 6 mutations” should read “3 of 5 mutations”.

 

Page 6, second column, line 16: In “Five, or 80%,” should read “Four, or 80%,”.

 

Page 6, second column, line 18: In “( $P=0.28$ )” should read “( $P=0.34$ )”.

 

Page 6, second column, line 20: In “(20.7 × 10⁹/L)” should read “(15.6 × 10⁹/L)”.

 

Table 4, column 2, line 6: In “H896*” should read “P896*”.

 

Table 4: Entire line 7 was excluded.

 

Table 5, line 2: In “40.2, 44.8 and 0.56” should read “47.4, 40.4 and 0.42”.

 

Table 5, line 4: In “50% (3), 59.3% (45) and 0.68” should read “60% (3), 57.9% (44) and 0.92”.

 

Table 5, line 5: In “50% (3), 40.7% (31)” should read “40% (2), 42.1% (32)”.

 

Table 5, line 19: In “50% (3), 51.4% (37) and 1.000” should read “40% (2), 52.7% (39) and 0.66”.

 

Table 5, line 20: In “50% (2), 30.9% (17) and 0.58” should read “40% (2), 29.2% (21) and 0.63”.

 

We changed Figure 3 as shown above.

Table 4

Description of somatic mutations found in gene DNMT3A.

Patient identification	Mutation	Allelic change	Exon	Type of mutation	FAB subtype	PCR	Risk group	Karyotype
39	D748N	G > A	19	Missense	M1	Negative	Intermediate	Normal
79	R882H	G > A	23	Missense	M1	Negative	Intermediate	Trisomy (8)(9)
4	R882H	G > A	23	Missense	M3	Negative	Intermediate	Normal
70	R882H	G > A	23	Missense	M2	Negative	Intermediate	Normal
41	P896*	A > G	23	Silent	M3	PML/RARα	Favorable	t(15;17)

Table 5

Clinical characteristics of patients with Acute Myeloid Leukemia with or without DNMT3A mutations.

Characteristics	Number of pts (%) DNMT3A mutated	Number of pts (%) DNMT3A not mutated	$P$
Age (median)	47.4	40.4	0.42
Sex
Male	60%  $(3)$	57.9% $(44)$	0.92
Female	40% $(2)$	42.1% $(32)$
Subtype FAB
M0	0%	7.2%   $(5)$
M1	60%   $(3)$	18.8%   $(13)$
M2	20%   $(1)$	30.4%   $(21)$	0.56
M3	20%   $(1)$	20.3%   $(14)$
M4	0%	18.8%   $(13)$
M5	0%	1.4%   $(1)$
Not M3	0%	2.9%   $(2)$
Risk groups
Favorable	20%   $(1)$	29.8%   $(17)$
Intermediate	80%   $(4)$	59.6%   $(34)$	1.000
Unfavorable	0%	10.5%   $(6)$
Leukocytes (×103) (median)	20.67	6.41	0.28
Death	40% $(2)$	52.7% $(39)$	0.66
Relapses	40% $(2)$	29.2% $(21)$	0.63
Refractory	20%   $(1)$	19.1%   $(13)$	0.96

[figure omitted; refer to PDF]