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© 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Introduction

Obesity is linked to altered activation in reward and control brain circuitry; however, the associated brain activity related to successful or unsuccessful weight loss (WL) is unclear.

Methods

Adults with obesity (N = 75) completed a baseline functional magnetic resonance imaging (fMRI) scan before entering a WL intervention (ie,3‐month diet and physical activity [PA] program). We conducted an exploratory analysis to identify the contributions of baseline brain activation, adherence behavior patterns, and the associated connections to WL at the conclusion of a 3‐month WL intervention. Food cue‐reactivity brain regions were functionally identified using fMRI to index brain activation to food vs nonfood cues. Food consumption, PA, and class attendance were collected weekly during the 3‐month intervention.

Results

The left middle frontal gyrus (L‐MFG, BA 46) and right middle frontal gyrus (R‐MFG; BA 9) were positively activated when viewing food compared with nonfood images. Structural equation modeling with bootstrapping was used to investigate a hypothesized path model and revealed the following significant paths: (1) attendance to 3‐month WL, (2) R‐MFG to attendance, and (3) indirect effects of R‐MFG through attendance on WL.

Conclusion

Findings suggest that brain activation to appetitive food cues predicts future WL through mediating session attendance, diet, and PA. This study contributes to the growing evidence of the importance of food cue reactivity and self‐regulation brain regions and their impact on WL outcomes.

Details

Title
Modeling interactions between brain function, diet adherence behaviors, and weight loss success
Author
Amanda N. Szabo‐Reed 1   VIAFID ORCID Logo  ; Martin, Laura E 2 ; Hu, Jinxiang 3 ; Hung‐Wen Yeh 3 ; Powell, Joshua 4   VIAFID ORCID Logo  ; Lepping, Rebecca J 5   VIAFID ORCID Logo  ; Patrician, Trisha M 3 ; Breslin, Florance J 6 ; Donnelly, Joseph E 1 ; Savage, Cary R 3 

 Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas 
 Department of Population Health Health, University of Kansas Medical Center, Kansas City, Kansas; Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas 
 Department of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas 
 Graduate School of Social Work, University of Denver, Denver, Colorado 
 Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas 
 Center for Brain, Biology and Behavior, University of Nebraska‐Lincoln, Lincoln, Nebraska 
Pages
282-292
Section
ORIGINAL ARTICLES
Publication year
2020
Publication date
Jun 2020
Publisher
John Wiley & Sons, Inc.
e-ISSN
20552238
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2410327990
Copyright
© 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.