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Copyright © 2017 Anne B. Gregory et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background and Aim. Obesity is associated with an increased risk of cardiovascular disease and may be associated with more severe coronary artery disease (CAD); however, the relationship between body mass index [BMI (kg/m2)] and CAD severity is uncertain and debatable. The aim of this study was to examine the relationship between BMI and angiographic severity of CAD. Methods. Duke Jeopardy Score (DJS), a prognostic tool predictive of 1-year mortality in CAD, was assigned to angiographic data of patients ≥18 years of age (N=8,079). Patients were grouped into 3 BMI categories: normal (18.5–24.9 kg/m2), overweight (25.0–29.9 kg/m2), and obese (≥30 kg/m2); and multivariable adjusted hazard ratios for 1-year all-cause and cardiac-specific mortality were calculated. Results. Cardiac risk factor prevalence (e.g., diabetes, hypertension, and hyperlipidemia) significantly increased with increasing BMI. Unadjusted all-cause and cardiac-specific 1-year mortality tended to rise with incremental increases in DJS, with the exception of DJS 6 (p<0.001). After adjusting for potential confounders, no significant association of BMI and all-cause (HR 0.70, 95% CI .48–1.02) or cardiac-specific (HR 1.11, 95% CI .64–1.92) mortality was found. Conclusions. This study failed to detect an association of BMI with 1-year all-cause or cardiac-specific mortality after adjustment for potential confounding variables.

Details

Title
The Relationship between Body Mass Index and the Severity of Coronary Artery Disease in Patients Referred for Coronary Angiography
Author
Gregory, Anne B 1 ; Lester, Kendra K 1 ; Gregory, Deborah M 2   VIAFID ORCID Logo  ; Twells, Laurie K 3   VIAFID ORCID Logo  ; Midodzi, William K 2 ; Pearce, Neil J 4 

 Department of Clinical Epidemiology, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6, 
 Department of Clinical Epidemiology, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6,; Department of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6, 
 Department of Clinical Epidemiology, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6,; School of Pharmacy, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6, 
 Department of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6,; Eastern Health, St. John’s, NL, Canada A1B 3V6, 
Editor
Robert Chen
Publication year
2017
Publication date
2017
Publisher
John Wiley & Sons, Inc.
ISSN
20908016
e-ISSN
20900597
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2410385306
Copyright
Copyright © 2017 Anne B. Gregory et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.