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Copyright © 2019 Qian-Feng Xiong et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

GLP-1 is a new type of antidiabetic agent that possesses many beneficial effects. Although its cardiovascular actions have been widely examined, little is known about GLP-1’s effects on the rat coronary artery (RCA) or about the mechanisms underpinning these effects. Here, we report that GLP-1 inhibits depolarization- or thromboxane receptor agonist (U46619)-induced RCA contraction in a dosage-dependent manner. Vasorelaxation was attenuated by denuding the endothelium, L-NAME (nitric oxide synthase inhibitor), and glyburide (KATP channel blocker) but was not affected by indomethacin (cyclooxygenase inhibitor), iberiotoxin [Ca2+-activated K+ channel (KCa) blocker], or 4-aminopyridine (KV channel blocker). Furthermore, GLP-1 increased outward K+ currents by enhancing the KATP channel in rat coronary arterial smooth muscle cells (RCASMCs). These results show that GLP-1 is an endothelial-dependent vasospasmolytic agent in the RCA and imply that the relaxant effect is regulated by enhancing KATP rather than KV or KCa currents in RCASMCs.

Details

Title
GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents
Author
Qian-Feng, Xiong 1   VIAFID ORCID Logo  ; Shao-Hua, Fan 2   VIAFID ORCID Logo  ; Xue-Wen, Li 3   VIAFID ORCID Logo  ; Niu, Yu 3   VIAFID ORCID Logo  ; Wang, Jing 3   VIAFID ORCID Logo  ; Zhang, Xin 2   VIAFID ORCID Logo  ; Yi-Fan, Chen 3   VIAFID ORCID Logo  ; Ya-Wei, Shi 2   VIAFID ORCID Logo  ; Li-Hui, Zhang 4   VIAFID ORCID Logo 

 Department of Cardiology, Fengcheng People’s Hospital, Fengcheng 331100, Jiangxi, China 
 Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan 030006, Shanxi, China 
 Department of Cardiology, Shanxi Dayi Hospital Affiliated to Shanxi Medical University, Taiyuan 030024, Shanxi, China 
 Department of Geriatrics, Shanxi Dayi Hospital Affiliated to Shanxi Medical University, Taiyuan 030024, Shanxi, China 
Editor
Anne Knowlton
Publication year
2019
Publication date
2019
Publisher
John Wiley & Sons, Inc.
ISSN
20908016
e-ISSN
20900597
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2410389317
Copyright
Copyright © 2019 Qian-Feng Xiong et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.