Abstract

Estimators of glomerular filtration rate (GFR) have been shown to be flawed in critically ill patients, especially for augmented renal clearance (ARC), commonly defined as a measured urinary creatinine clearance (CrCl) ≥ 130 ml/min/1.73 m2 [1]. [...]measuring CrCl should be performed in daily practice on the intensive care unit (ICU). [...]the aim of this study is to define the most precise GFR estimator, which can then be used to detect ARC when measured CrCl is unavailable. [...]the performance of these cut-offs was evaluated in an external single-center (Leuven, January 2016–December 2016) validation set by receiver-operating characteristics (ROC) curve analysis, using 2000 bootstrap replicates.

Details

Title
Can augmented renal clearance be detected using estimators of glomerular filtration rate?
Author
Gijsen, Matthias  VIAFID ORCID Logo  ; Wilmer, Alexander; Meyfroidt, Geert; Wauters, Joost; Spriet, Isabel
Pages
1-4
Section
Research Letter
Publication year
2020
Publication date
2020
Publisher
BioMed Central
ISSN
13648535
e-ISSN
1366609X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s13054-020-03057-4
ProQuest document ID
2414647586
Copyright
© 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.