Abstract
{Figure 1}{Figure 2}{Figure 3}{Figure 4}{Table 1} In all cases, drug-induced skin pigmentation was ruled out and epicutaneous patch tests were performed with GEIDAC's (Spanish Research Group on Contact Dermatitis and Cutaneous Allergy) standard battery which showed negative results. Histological examination was carried out in all cases and it revealed interface dermatitis with vacuolar degeneration of the basal cells, a dense lympho-mononuclear perivascular and perifollicular infiltrate with abundant melanophages in the papillary and high reticular dermis. [...]when we come across a patient with generalized facial pigmentation, pigmented lupus erythematosus should always be consdered and histological evaluation should be done to confirm this diagnosis.
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Details
1 Department of Dermatology, Institute I + 12, Universitary Hospital 12 de Octubre, Complutense University, Madrid
2 Department of Dermatology, Hospital Fundación Jiménez Díaz, Madrid
3 Department of Anatomopathology, Universitary Hospital 12 de Octubre, Madrid