Abstract

Background

Intestinal and diffuse gastric adenocarcinomas differ in clinical, epidemiological and molecular features. However, most of the concepts related to the intestinal-type are translated to gastric adenocarcinoma in general; thus, the peculiarities of the diffuse-type are underappreciated.

Results

Besides its growing importance, there are many gaps about the diffuse-type carcinogenesis and, as a result, its epidemiologic and pathogenetic features remain poorly understood.

Conclusions

Alternative hypotheses to explain these features are discussed, including the role of the gastric microbiota, medical therapies, and modifications in the stomach’s microenvironment.

Details

Title
The diffuse-type gastric cancer epidemiology enigma
Author
Paulo Pimentel Assumpção; Williams Fernandes Barra  VIAFID ORCID Logo  ; Ishak, Geraldo; Luiz Gonzaga Vaz Coelho; Fernandez Coimbra, Felipe José; Freitas, Helano Carioca; Dias-Neto, Emmanuel; M. Constanza Camargo; Szklo, Moyses
Pages
1-7
Section
Debate
Publication year
2020
Publication date
2020
Publisher
BioMed Central
e-ISSN
1471230X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2424746106
Copyright
© 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.