Abstract

Background

Rheumatoid arthritis (RA) is a long-term autoimmune disorder that mostly affects the joints and leads to the destruction of cartilage. An RA model in non-human primates is especially useful because of their close phylogenetic relationship to humans in terms of cross-reactivity to compounds developed using modern drug technologies.

Methods

We used a collagen-induced arthritis (CIA) model in Macaca fascicularis. CIA was induced by the immunization of chicken type II collagen. Swelling was measured as the longitudinal and transverse axes of 16 proximal interphalangeal joints.

Results

A new system for visual evaluation was created, with a perfect score of 16. Individual behavioral analysis was also conducted. Serum was collected once a week after the first immunization. Blood chemistry and inflammatory cytokine parameters were higher in the CIA group than in the wild type group.

Conclusion

In conclusion, we established CIA in M. fascicularis, and the results can be used for drug evaluation models.

Details

Title
The establishment of a rheumatoid arthritis primate model in Macaca fascicularis
Author
Na, Hyun Sik; Seon-yeong, Lee; Hong Ki Min; Wan-je, Park; Jung-hwan, Lee; Ka-hee Cho; Shin-hee, Hong; Dae-hoon, Kim; Jhun, Jooyeon; Jeong-Won, Choi; Sung-Min, Kim; Seung-Ki Kwok; Mi-La Cho  VIAFID ORCID Logo  ; Park, Sung-Hwan
Pages
1-10
Section
Research
Publication year
2020
Publication date
2020
Publisher
BioMed Central
e-ISSN
14795876
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s12967-020-02402-z
ProQuest document ID
2424775084
Copyright
© 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.