It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Vitamin D supplementation is widely used. However, there is no consensus on the use and dosage of this supplement and the existing recommendations arise from studies based on the benefits that this nutrient can facilitate in bones. In addition, individual genetics can influence the response to supplementation, therefore, research involving monozygotic twins aims to reduce these differences in phenotypic responses. The objective of this randomised controlled study is to examine the effect of vitamin D supplementation on body composition and the expression of the vitamin D receptor (VDR) mRNA. An intervention was performed through supplementation with cholecalciferol at the concentration of 2000 IU in 90 healthy adult monozygotic twins (male or female pairs) for 2 months. The findings showed that serum vitamin D concentration increased by 65% and VDR gene expression sixty times (p = 0.001). Changes in body composition parameters were observed regarding body fat and lean mass. Our results indicate that an increase in serum vitamin D concentration may have potential therapeutic implications.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Federal University of Rio Grande Do Norte, Department of Health Sciences, Natal, Brazil (GRID:grid.411233.6) (ISNI:0000 0000 9687 399X)
2 Federal University of Rio Grande Do Norte, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Natal, Brazil (GRID:grid.411233.6) (ISNI:0000 0000 9687 399X)
3 University of Sao Paulo, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, Sao Paulo, Brazil (GRID:grid.11899.38) (ISNI:0000 0004 1937 0722)
4 Federal University of Rio Grande Do Norte, Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Natal, Brazil (GRID:grid.411233.6) (ISNI:0000 0000 9687 399X); Federal University of Rio Grande Do Norte, Department of Clinical and Toxicological Analyses, Natal, Brazil (GRID:grid.411233.6) (ISNI:0000 0000 9687 399X)
5 Federal University of Rio Grande Do Norte, Department of Health Sciences, Natal, Brazil (GRID:grid.411233.6) (ISNI:0000 0000 9687 399X); Federal University of Rio Grande Do Norte, Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Natal, Brazil (GRID:grid.411233.6) (ISNI:0000 0000 9687 399X); Federal University of Rio Grande Do Norte, Department of Clinical and Toxicological Analyses, Natal, Brazil (GRID:grid.411233.6) (ISNI:0000 0000 9687 399X)