Abstract

To reveal the impacts of smoking on genetic architecture of human body weight, we conducted a genome-wide association study on 5,336 subjects in four ethnic populations from MESA (The Multi-Ethnic Study of Atherosclerosis) data. A full genetic model was applied to association mapping for analyzing genetic effects of additive, dominance, epistasis, and their ethnicity-specific effects. Both the unconditional model (base) and conditional model including smoking as a cofactor were investigated. There were 10 SNPs involved in 96 significant genetic effects detected by the base model, which accounted for a high heritability (61.78%). Gene ontology analysis revealed that a number of genetic factors are related to the metabolic pathway of benzopyrene, a main compound in cigarettes. Smoking may play important roles in genetic effects of dominance, dominance-related epistasis, and gene-ethnicity interactions on human body weight. Gene effect prediction shows that the genetic effects of smoking cessation on body weight vary from different populations.

Details

Title
Conditional and unconditional genome-wide association study reveal complicate genetic architecture of human body weight and impacts of smoking
Author
Xu, Ting 1 ; Monir Md Mamun 2 ; Xiang-Yang, Lou 3 ; Xu, Haiming 2   VIAFID ORCID Logo  ; Zhu, Jun 1   VIAFID ORCID Logo 

 Zhejiang University, Department of Mathematics, Hangzhou, China (GRID:grid.13402.34) (ISNI:0000 0004 1759 700X) 
 Zhejiang University, Institute of Bioinformatics, Hangzhou, China (GRID:grid.13402.34) (ISNI:0000 0004 1759 700X) 
 University of Florida, Department of Biostatistics, Gainesville, USA (GRID:grid.15276.37) (ISNI:0000 0004 1936 8091) 
Publication year
2020
Publication date
2020
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2426007890
Copyright
© The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.