Abstract

Since its genome details are publically available, the mosquito Aedes albopictus has become the central stage of attention for deciphering multiple biological and evolutionary aspects at the root of its success as an invasive species. Its genome of 1,967 Mb harbours an unusual high number of non-retroviral integrated RNA virus sequences (NIRVS). NIRVS are enriched in piRNA clusters and produce piRNAs, suggesting an antiviral effect. Here, we investigated the evolutionary history of NIRVS in geographically distant Ae. albopictus populations by comparing genetic variation as derived by neutral microsatellite loci and seven selected NIRVS. We found that the evolution of NIRVS was far to be neutral with variations both in their distribution and sequence polymorphism among Ae. albopictus populations. The Flaviviral elements AlbFlavi2 and AlbFlavi36 were more deeply investigated in their association with dissemination rates of dengue virus (DENV) and chikungunya virus (CHIKV) in Ae. albopictus at both population and individual levels. Our results show a complex association between NIRVS and DENV/CHIKV opening a new avenue for investigating the functional role of NIRVS as antiviral elements shaping vector competence of mosquitoes to arboviruses.

Details

Title
Evolution and biological significance of flaviviral elements in the genome of the arboviral vector Aedes albopictus
Author
Houé, Vincent 1 ; Gabiane, Gaelle 2 ; Dauga, Catherine 3 ; Suez, Marie 4 ; Madec, Yoann 5 ; Mousson, Laurence 2 ; Marconcini, Michele 6   VIAFID ORCID Logo  ; Pei-Shi, Yen 2 ; de Lamballerie, Xavier 7 ; Bonizzoni, Mariangela 6   VIAFID ORCID Logo  ; Anna-Bella Failloux 2   VIAFID ORCID Logo 

1  Department of Virology, Arboviruses and Insect Vectors, Institut Pasteur, Paris, France; Sorbonne Université, Collège Doctoral, Paris, France 
2  Department of Virology, Arboviruses and Insect Vectors, Institut Pasteur, Paris, France 
3  Institut Pasteur, Center for Bioinformatics, BioStatistics and Integrative Biology (C3BI), Paris, France 
4  Institut de Biologie Paris-Seine, Paris, France 
5  Department of Infection and Epidemiology, Institut Pasteur, Epidemiology of Emerging Diseases, Paris, France 
6  Department of Biology and Biotechnology, University of Pavia, Pavia, Italy 
7  Aix Marseille Université, IRD French Institute of Research for Development, EHESP French School of Public Health, EPV UMR_D 190 ‘Emergence des Pathologies Virales’, Marseille, France; IHU Méditerranée Infection, APHM Public Hospitals of Marseille, Marseille, France 
Pages
1265-1279
Publication year
2019
Publication date
2019
Publisher
Taylor & Francis Ltd.
e-ISSN
22221751
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1080/22221751.2019.1657785
ProQuest document ID
2427525871
Copyright
© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.