Abstract

Background

Undifferentiated carcinoma of the colon is rare, and its prognosis is very poor. We report a case of undifferentiated carcinoma of the colon with rhabdoid features developed during treatment of non-small lung carcinoma (NSCLC) with pembrolizumab.

Case presentation

A 58-year-old man was diagnosed with transverse colon cancer during chemotherapy with pembrolizumab for NSCLC. Laparoscopic right hemicolectomy was performed. The histopathological diagnosis was undifferentiated carcinoma with rhabdoid features and lymph node metastasis. Immunohistochemically, programmed death ligand 1 (PD-L1) showed positivity. The microsatellite instability (MSI) status was low. He continued to receive pembrolizumab for NSCLC, and there have been no signs of colon cancer recurrence and progression of NSCLC for 15 months.

Conclusion

We present the case of an undifferentiated carcinoma of the transverse colon with rhabdoid features. The development of the tumor with the expression of PD-L1 during pembrolizumab might have been associated with the low MSI.

Details

Title
Undifferentiated carcinoma of the transverse colon with rhabdoid features that developed during treatment of non-small cell lung carcinoma with pembrolizumab: a case report
Author
Ashitomi Yuya 1   VIAFID ORCID Logo  ; Yano Mitsuhiro 1 ; Kono Michihisa 1 ; Suzuki, Takefumi 1 ; Kawamura Ichiro 1 ; Okazaki Shinji 1 ; Kamio Yukinori 1 ; Hachiya Osamu 1 ; Urano Yuka 2 ; Fuyuhiko, Motoi 1 

1  Yamagata University Faculty of Medicine, First Department of Surgery, Yamagata City, Japan (GRID:grid.268394.2) (ISNI:0000 0001 0674 7277) 
2  Yamagata University Faculty of Medicine, Department of Pathological Diagnostics, Yamagata City, Japan (GRID:grid.268394.2) (ISNI:0000 0001 0674 7277) 
Publication year
2020
Publication date
Dec 2020
Publisher
International Academic Publishing Co Ltd.
e-ISSN
21987793
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s40792-020-00963-1
ProQuest document ID
2429922009
Copyright
© The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.