Abstract

We examined the association between sarco/endoplasmic reticulum calcium ATPase (SERCA) expression and glycated hemoglobin (HbA1c) levels since alterations in this protein expression are associated with the genesis of insulin resistance. HbA1c levels and SERCA protein expression from platelets of Mexican patients diagnosed with type 2 diabetes mellitus (T2DM) were analyzed showing lower values of SERCA expression against the normal values we find in healthy people. Interestingly, as diabetes condition got worse; SERCA protein expression decreased gradually until it was undetectable. The results showed an inverse correlation between HbA1c and SERCA protein expression in T2DM patients. .

Details

Title
Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus
Author
Galindo-Hernandez, Octavio; Machado-Contreras, Jesus Rene; Martinez-Corella, Rodrigo; Romero-Garcia, Tatiana; Vazquez-Jimenez, J Gustavo
Pages
1226-1228
Publication year
2020
Publication date
2020
Publisher
Termedia Publishing House
ISSN
17341922
e-ISSN
18969151
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.5114/aoms.2020.97970
ProQuest document ID
2432856919
Copyright
© 2020. This work is published under http://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.