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© 2020. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Although micro RNA (miRNA) expression profiles are widely investigated in renal cell carcinoma (RCC), their potential roles for affecting RCC initiation and progression remain largely unknown. Here, we examined the aberrant expression profiles of miRNAs inhuman metastatic RCC tissues based on Gene Expression Omnibus (GSE37989). We further validated them iRNAs expression data in the largest clinical dataset: The Cancer Genome Atlas (TCGA). And cell adhesion and migration abilities and epithelial me senchymal transition (EMT) related proteins were assessed in both normal and tumor RCC cell lines. We suggest that hsa-miR-143 is a potential tumor suppressor in RCC as its down regulation positively correlated with adverse prognosis. Biologically, cell adhesion, migration, and EMT were dramatically inhibited by miR-143. Mechanistically, we found that miR-143 targets ABL proto-oncogene 2 (ABL2), which was also found to be an indicator for poor survival in TCGA database. Our results have important implications in understanding functions of miRNAs in metastatic RCC and will provide a basis for further clinical application.

Details

Title
miR-143 inhibits renal cell carcinoma cells metastatic potential by suppressing ABL2
Author
Xu, Bin 1 ; Wang, Can 1 ; Ya-Li, Wang 1 ; Shu-Qiu, Chen 1 ; Wu, Jian-Ping 1 ; Wei-Dong, Zhu 1 ; Chun-Ying, Wang 1 ; Guan, Han 2 ; Guan, Chao 3 ; Zong-Hao You 1 ; Chen, Ming 1   VIAFID ORCID Logo 

 Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China 
 Department of Urology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China 
 Department of Urology, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, China 
Pages
592-598
Section
ORIGINAL ARTICLES
Publication year
2020
Publication date
Aug 2020
Publisher
John Wiley & Sons, Inc.
ISSN
1607551X
e-ISSN
24108650
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2434348074
Copyright
© 2020. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.