Abstract

It is suggested that neurodevelopmental abnormalities are involved in the disease mechanisms of psychotic disorders. Although cellular adhesion molecules (CAMs) participate in neurodevelopment, modulate blood–brain barrier permeability, and facilitate leukocyte migration, findings concerning their systemic levels in adults with psychosis are inconsistent. We examined plasma levels and mRNA expression in peripheral blood mononuclear cells (PBMCs) of selected CAMs in adolescents with early-onset psychosis (EOP) aged 12–18 years (n = 37) and age-matched healthy controls (HC) (n = 68). EOP patients exhibited significantly lower circulating levels of soluble platelet selectin (~−22%) and soluble vascular cell adhesion molecule-1 (~−14%) than HC. We found no significant associations with symptom severity. PSEL mRNA expression was increased in PBMCs of patients and significantly negatively correlated to duration of illness. These findings suggest a role for CAMs in the pathophysiology of psychotic disorders.

Details

Title
Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis
Author
Wedervang-Resell Kirsten 1   VIAFID ORCID Logo  ; Ueland Thor 2 ; Aukrust Pål 3 ; Friis Svein 4 ; Holven, Kirsten B 5 ; H Johannessen Cecilie 6 ; Lekva Tove 7 ; Lonning Vera 8 ; Smelror, Runar E 8 ; Szabo Attila 6 ; Andreassen, Ole A 1 ; Myhre, Anne M 9 ; Agartz Ingrid 10 

1  University of Oslo, NORMENT Center of Excellence, Institute of Clinical Medicine, Oslo, Norway (GRID:grid.5510.1) (ISNI:0000 0004 1936 8921); Oslo University Hospital, Division of Mental Health and Addiction, Department of Psychiatric Research and Development, Oslo, Norway (GRID:grid.55325.34) (ISNI:0000 0004 0389 8485) 
2  Oslo University Hospital, Rikshospitalet, Research Institute of Internal Medicine, Oslo, Norway (GRID:grid.55325.34) (ISNI:0000 0004 0389 8485); University of Tromsø, K.G. Jebsen Thrombosis Research and Expertise Center, Tromsø, Norway (GRID:grid.10919.30) (ISNI:0000000122595234); University of Oslo, Institute of Clinical Medicine, Oslo, Norway (GRID:grid.5510.1) (ISNI:0000 0004 1936 8921) 
3  Oslo University Hospital, Rikshospitalet, Research Institute of Internal Medicine, Oslo, Norway (GRID:grid.55325.34) (ISNI:0000 0004 0389 8485); University of Oslo, Institute of Clinical Medicine, Oslo, Norway (GRID:grid.5510.1) (ISNI:0000 0004 1936 8921); Oslo University Hospital, Rikshospitalet, Section of Clinical Immunology and Infectious Diseases, Oslo, Norway (GRID:grid.55325.34) (ISNI:0000 0004 0389 8485) 
4  Oslo University Hospital, Division of Mental Health and Addiction, Department of Psychiatric Research and Development, Oslo, Norway (GRID:grid.55325.34) (ISNI:0000 0004 0389 8485); University of Oslo, Institute of Clinical Medicine, Oslo, Norway (GRID:grid.5510.1) (ISNI:0000 0004 1936 8921) 
5  University of Oslo, Department of Nutrition, Institute for Basic Medical Sciences, Oslo, Norway (GRID:grid.5510.1) (ISNI:0000 0004 1936 8921) 
6  University of Oslo, NORMENT Center of Excellence, Institute of Clinical Medicine, Oslo, Norway (GRID:grid.5510.1) (ISNI:0000 0004 1936 8921) 
7  Oslo University Hospital, Rikshospitalet, Research Institute of Internal Medicine, Oslo, Norway (GRID:grid.55325.34) (ISNI:0000 0004 0389 8485) 
8  University of Oslo, NORMENT Center of Excellence, Institute of Clinical Medicine, Oslo, Norway (GRID:grid.5510.1) (ISNI:0000 0004 1936 8921); Diakonhjemmet Hospital, Department of Psychiatric Research, Oslo, Norway (GRID:grid.413684.c) (ISNI:0000 0004 0512 8628) 
9  Oslo University Hospital, Division of Mental Health and Addiction, Department of Psychiatric Research and Development, Oslo, Norway (GRID:grid.55325.34) (ISNI:0000 0004 0389 8485); University of Oslo, Child and Adolescent Psychiatry Unit, Division of Mental Health and Addiction, Institute of Clinical Medicine, Oslo, Norway (GRID:grid.5510.1) (ISNI:0000 0004 1936 8921) 
10  University of Oslo, NORMENT Center of Excellence, Institute of Clinical Medicine, Oslo, Norway (GRID:grid.5510.1) (ISNI:0000 0004 1936 8921); Diakonhjemmet Hospital, Department of Psychiatric Research, Oslo, Norway (GRID:grid.413684.c) (ISNI:0000 0004 0512 8628); Karolinska Institutet, Centre for Psychiatric Research, Department of Clinical Neuroscience, Stockholm, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626) 
Publication year
2020
Publication date
2020
Publisher
Nature Publishing Group
e-ISSN
2334-265X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41537-020-00112-5
ProQuest document ID
2435011268
Copyright
© The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.