Abstract

Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including disease pathogenesis. With the development of innovative technologies, an increasing number of novel ncRNAs have been uncovered; information about their prominent tissue-specific expression patterns, various interaction networks, and subcellular locations will undoubtedly enhance our understanding of their potential functions. Here, we summarized the principles and innovative methods for identifications of novel ncRNAs that have potential functional roles in cancer biology. Moreover, this review also provides alternative ncRNA databases based on high-throughput sequencing or experimental validation, and it briefly describes the current strategy for the clinical translation of cancer-associated ncRNAs to be used in diagnosis.

Details

Title
Principles and innovative technologies for decrypting noncoding RNAs: from discovery and functional prediction to clinical application
Author
Yu-Meng, Sun; Yue-Qin, Chen  VIAFID ORCID Logo 
Pages
1-27
Section
Review
Publication year
2020
Publication date
2020
Publisher
BioMed Central
e-ISSN
17568722
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2435161949
Copyright
© 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.