Abstract

There is an urgent need for drugs, therapies and vaccines to be available to protect the human population against COVID-19. One of the first approaches taken in the COVID-19 global response was to consider repurposing licensed drugs. This commentary highlights an extraordinary international collaborative effort of independent researchers who have recently all come to the same conclusion—that chloroquine or hydroxchloroquine are unlikely to provide clinical benefit against COVID-19.

Details

Title
Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients
Author
Funnell S G P 1   VIAFID ORCID Logo  ; Dowling, W E 2 ; Muñoz-Fontela, C 3 ; P-S, Gsell 4 ; Ingber, D E 5   VIAFID ORCID Logo  ; Hamilton, G A 6 ; Delang, L 7   VIAFID ORCID Logo  ; Rocha-Pereira, J 7 ; Kaptein, S 7 ; Dallmeier, K H 7 ; Neyts, J 7 ; Rosenke, K 8 ; de, Wit E 8   VIAFID ORCID Logo  ; Feldmann, H 8   VIAFID ORCID Logo  ; Maisonnasse, P 9   VIAFID ORCID Logo  ; Le Grand R 9   VIAFID ORCID Logo  ; Frieman, M B 10   VIAFID ORCID Logo  ; Coleman, C M 11 

1  Public Health England, National Infection Service, Salisbury, UK (GRID:grid.271308.f) (ISNI:0000 0004 5909 016X) 
2  Coalition for Epidemic Preparedness Innovations, Washington, USA (GRID:grid.271308.f) 
3  Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany (GRID:grid.424065.1) (ISNI:0000 0001 0701 3136) 
4  World Health Organisation, Geneva, Switzerland (GRID:grid.3575.4) (ISNI:0000000121633745) 
5  Harvard University, Wyss Institute for Biologically Inspired Engineering, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X) 
6  Emulate Inc., Boston, USA (GRID:grid.38142.3c) 
7  KU Leuven, Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, Global Virus Network, Leuven, Belgium (GRID:grid.5596.f) (ISNI:0000 0001 0668 7884) 
8  National Institute of Health, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Hamilton, USA (GRID:grid.94365.3d) (ISNI:0000 0001 2297 5165) 
9  Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases » (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France (GRID:grid.7429.8) (ISNI:0000000121866389) 
10  University of Maryland School of Medicine, Department of Microbiology and Immunology, Baltimore, USA (GRID:grid.411024.2) (ISNI:0000 0001 2175 4264) 
11  University of Nottingham, Queen’s Medical Centre, School of Life Sciences, Nottingham, UK (GRID:grid.411024.2) 
Publication year
2020
Publication date
2020
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-020-17907-w
ProQuest document ID
2437277631
Copyright
© Crown 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.