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© 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Tumor-infiltrating T cell rescue by programmed cell death receptor-1 (PD-1)/PD-1 ligand-1 (PD-L1) immune checkpoint blockade is a recommended treatment for malignant diseases, including metastatic non-small-cell lung cancer (mNSCLC), malignant melanoma (MM), head and neck, kidney, and urothelial cancer. Monoclonal antibodies (mAbs) against either PD-1 or PD-L1 are active agents for these patients; however, their use may be complicated by unpredictable immune-related adverse events (irAEs), including immune-related pneumonitis (IRP). We carried out a retrospective multi-institutional statistical analysis to investigate clinical and biological parameters correlated with IRP rate on a cohort of 256 patients who received real-world treatment with PD-1/PD-L1 blocking mAbs. An independent radiological review board detected IRP in 29 patients. We did not find statistical IRP rate correlation with gender, tumor type, specific PD-1 or PD-L1 blocking mAbs, radiation therapy, inflammatory profile, or different irAEs. A higher IRP risk was detected only in mNSCLC patients who received metronomic chemotherapy +/− bevacizumab compared with other treatments prior PD-1/PD-L1 blockade. Moreover, we detected a strong correlation among the IRP rate and germinal expression of HLA-B*35 and DRB1*11, alleles associated to autoimmune diseases. Our findings may have relevant implications in predicting the IRP rate in mNSCLC patients receiving PD-1/PD-L1 blockade and need to be validated on a larger patient series.

Details

Title
HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis
Author
Correale, Pierpaolo  VIAFID ORCID Logo  ; Saladino, Rita Emilena; Giannarelli, Diana; Sergi, Andrea; Mazzei, Maria Antonietta; Bianco, Giovanna; Giannicola, Rocco; Iuliano, Eleonora; Forte, Iris Maria  VIAFID ORCID Logo  ; Natale Daniele Calandruccio; Antonia Consuelo Falzea; Strangio, Alessandra; Nardone, Valerio  VIAFID ORCID Logo  ; Pastina, Pierpaolo; Tini, Paolo; Luce, Amalia  VIAFID ORCID Logo  ; Caraglia, Michele  VIAFID ORCID Logo  ; Caracciolo, Daniele; Mutti, Luciano  VIAFID ORCID Logo  ; Tassone, Pierfrancesco; Pirtoli, Luigi; Giordano, Antonio  VIAFID ORCID Logo  ; Tagliaferri, Pierosandro
First page
1964
Publication year
2020
Publication date
2020
Publisher
MDPI AG
e-ISSN
20734409
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2438433531
Copyright
© 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.