Full text

Turn on search term navigation

Copyright © 2020 Dina Rady et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0/

Abstract

Mesenchymal stem/progenitor cells (MSCs) are key players in regenerative medicine, relying principally on their differentiation/regeneration potential, immunomodulatory properties, paracrine effects, and potent homing ability with minimal if any ethical concerns. Even though multiple preclinical and clinical studies have demonstrated remarkable properties for MSCs, the clinical applicability of MSC-based therapies is still questionable. Several challenges exist that critically hinder a successful clinical translation of MSC-based therapies, including but not limited to heterogeneity of their populations, variability in their quality and quantity, donor-related factors, discrepancies in protocols for isolation, in vitro expansion and premodification, and variability in methods of cell delivery, dosing, and cell homing. Alterations of MSC viability, proliferation, properties, and/or function are also affected by various drugs and chemicals. Moreover, significant safety concerns exist due to possible teratogenic/neoplastic potential and transmission of infectious diseases. Through the current review, we aim to highlight the major challenges facing MSCs’ human clinical translation and shed light on the undergoing strategies to overcome them.

Details

Title
Mesenchymal Stem/Progenitor Cells: The Prospect of Human Clinical Translation
Author
Rady, Dina 1   VIAFID ORCID Logo  ; Abbass, Marwa M S 1   VIAFID ORCID Logo  ; El-Rashidy, Aiah A 2   VIAFID ORCID Logo  ; Sara El Moshy 1   VIAFID ORCID Logo  ; Israa Ahmed Radwan 1   VIAFID ORCID Logo  ; Dörfer, Christof E 3 ; Fawzy El-Sayed, Karim M 4   VIAFID ORCID Logo 

 Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt; Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt 
 Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt; Biomaterials Department, Faculty of Dentistry, Cairo University, Cairo, Egypt 
 Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany 
 Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt; Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany; Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt 
Editor
Kar Wey Yong
Publication year
2020
Publication date
2020
Publisher
John Wiley & Sons, Inc.
ISSN
1687966X
e-ISSN
16879678
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2440440201
Copyright
Copyright © 2020 Dina Rady et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0/