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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The development of smart and intelligent regenerative biomaterials for skeletal muscle tissue engineering is an ongoing challenge, owing to the requirement of achieving biomimetic systems able to communicate biological signals and thus promote optimal tissue regeneration. Electrospinning is a well-known technique to produce fibers that mimic the three dimensional microstructural arrangements, down to nanoscale and the properties of the extracellular matrix fibers. Natural and synthetic polymers are used in the electrospinning process; moreover, a blend of them provides composite materials that have demonstrated the potential advantage of supporting cell function and adhesion. Recently, the decellularized extracellular matrix (dECM), which is the noncellular component of tissue that retains relevant biological cues for cells, has been evaluated as a starting biomaterial to realize composite electrospun constructs. The properties of the electrospun systems can be further improved with innovative procedures of functionalization with biomolecules. Among the various approaches, great attention is devoted to the “click” concept in constructing a bioactive system, due to the modularity, orthogonality, and simplicity features of the “click” reactions. In this paper, we first provide an overview of current approaches that can be used to obtain biofunctional composite electrospun biomaterials. Finally, we propose a design of composite electrospun biomaterials suitable for skeletal muscle tissue regeneration.

Details

Title
Smart ECM-Based Electrospun Biomaterials for Skeletal Muscle Regeneration
Author
Politi, Sara 1 ; Carotenuto, Felicia 2   VIAFID ORCID Logo  ; Rinaldi, Antonio 3   VIAFID ORCID Logo  ; Paolo Di Nardo 4 ; Manzari, Vittorio 5 ; Albertini, Maria Cristina 6   VIAFID ORCID Logo  ; Araneo, Rodolfo 7   VIAFID ORCID Logo  ; Ramakrishna, Seeram 8   VIAFID ORCID Logo  ; Teodori, Laura 9 

 Department of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, CR Frascati, 00044 Rome, Italy; [email protected] (S.P.); [email protected] (F.C.); Department of Clinical Science and Translational Medicine, University of Rome “Tor Vergata”, 00133 Rome Italy; [email protected] (P.D.N.); [email protected] (V.M.) 
 Department of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, CR Frascati, 00044 Rome, Italy; [email protected] (S.P.); [email protected] (F.C.); Department of Clinical Science and Translational Medicine, University of Rome “Tor Vergata”, 00133 Rome Italy; [email protected] (P.D.N.); [email protected] (V.M.); Interdepartmental Center for Regenerative Medicine (CIMER), University of Rome “Tor Vergata”, 00133 Rome, Italy 
 Department of Sustainability (SSPT), ENEA, 00123 Rome, Italy; [email protected] 
 Department of Clinical Science and Translational Medicine, University of Rome “Tor Vergata”, 00133 Rome Italy; [email protected] (P.D.N.); [email protected] (V.M.); Interdepartmental Center for Regenerative Medicine (CIMER), University of Rome “Tor Vergata”, 00133 Rome, Italy; L.L. Levshin Institute of Cluster Oncology, I. M. Sechenov First Medical University, Moscow 119991, Russia 
 Department of Clinical Science and Translational Medicine, University of Rome “Tor Vergata”, 00133 Rome Italy; [email protected] (P.D.N.); [email protected] (V.M.) 
 Department of Biomolecular Sciences, Urbino University “Carlo Bo”, 61029 Urbino, Italy; [email protected] 
 Department of Astronautics Electrical and Energy Engineering (DIAEE), University of Rome “La Sapienza”, 00184 Rome, Italy; [email protected] 
 Centre for Nanofibers and Nanotechnology, Department of Mechanical Engineering, National University of Singapore, Singapore 119260, Singapore; [email protected] 
 Department of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, CR Frascati, 00044 Rome, Italy; [email protected] (S.P.); [email protected] (F.C.); Interdepartmental Center for Regenerative Medicine (CIMER), University of Rome “Tor Vergata”, 00133 Rome, Italy 
First page
1781
Publication year
2020
Publication date
2020
Publisher
MDPI AG
e-ISSN
20794991
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2442032821
Copyright
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.