Abstract

Campomanesia phaea (Myrtaceae), popularly known as cambuci, is one of several species of plants producing comestible fruits, largely used in human nutrition. Despite its consumption and economic potential, limited scientific research is available on the Campomanesia, especially those related to its therapeutic benefits. It is reported by traditional medicine the use of the plant in the treatment of different disorders, such as cardiovascular and nervous system disturbances. So, the aim of this study was to carry out the pharmacological evaluation of the hydro-alcoholic extract (HAE) of Campomanesia fruits in rats by screening consisting of tests: a) neuropharmacological observation, b) test on the cardiovascular system. The HAE, prepared from the extraction of fruits with water/ethanol, was concentrated and freeze-dried. Behavioral responses in rats were investigated in open field test and the cardiovascular actions were investigated by a register of indirect blood pressure and the register of spontaneous beating rate right atrium. The results revealed that HAE induced grooming, hypotension and bradycardia. So, this study identified an action on the central nervous system, represented by grooming, and a cardiovascular activity of Campomanesia. The hypotension, attributed in part to bradycardia, was not related to a cholinergic effect, discarding a possible cholinomimetic action of the plant that could justify both cardiovascular and central actions.

Alternate abstract:

Campomanesia phaea (Myrtaceae), popularmente conhecida como cambuci, é uma das várias espécies de plantas que produzem frutos comestíveis amplamente utilizados na nutriçâo humana. Apesar de seu consumo e potencial económico, há poucas pesquisas científicas sobre a Campomanesia, especialmente aquelas relacionadas aos seus beneficios terapéuticos. É relatado pela medicina tradicional o uso da planta no tratamento de diferentes disturbios, tais como disturbios do sistema nervoso e cardiovascular. Assim, o objetivo deste estudo foi realizar a avaliaçâo farmacológica do extrato hidroalcoólico (EHA) dos frutos de Campomanesia phaea em ratos através de triagem composta pelos testes: a) observaçâo neurofarmacológica, b) testes no sistema cardiovascular. O EHA, preparado a partir da extraçâo de frutos com água/etanol, foi concentrado e liofilizado. As respostas comportamentais em ratos foram investigadas em teste de campo aberto e as açöes cardiovasculares foram investigadas pelo registro da pressäo arterial indireta e o registro da taxa de batimentos cardíacos espontáneos em preparaçöes isoladas de átrio direito. Os resultados revelaram que EHA induziu grooming, hipotensäo e bradicardia. Assim, este estudo identificou uma açâo da Campomanesia sobre o sistema nervoso central, representada por grooming, e uma atividade cardiovascular. A hipotensäo, atribuída em parte a bradicardia, näo está relacionada a um efeito colinérgico, descartando uma possivel açâo colinomimética da planta que pudesse justificar tanto as açöes cardiovasculares quanto as centrais.

Details

Title
Pharmacological evaluation of the hydro-alcoholic extract of Campomanesia phaea fruits in rats
Author
Wczassek, L R 1 ; Pontes, V C B 1 ; Gamberini, M T 1 

 Departamento de Ciencias Fisiológicas da Santa Casa de Säo Paulo, Faculdade de Ciencias Médicas da Santa Casa de Säo Paulo, Rua Dr. Cesário Motta Jr., 61, CEP 01221-020, Säo Paulo, SP, Brasil 
Pages
601-606
Section
Original Article
Publication year
2020
Publication date
Jul-Sep 2020
Publisher
Instituto Internacional de Ecologia
ISSN
15196984
e-ISSN
16784375
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2444522719
Copyright
© 2020. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.