Full text

Turn on search term navigation

© 2020. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Aims

Response to cardiac resynchronization therapy (CRT) is known to be associated with a number of clinical characteristics, including QRS duration and morphology, gender, height, and the aetiology of heart failure (HF). We assessed the relation of gender and baseline characteristics with QRS duration and Kansas City Cardiomyopathy Questionnaire.

Methods and results

AdaptResponse is a global randomized trial. The trial enrolled CRT‐indicated patients with New York Heart Association classes II–IV HF, left bundle branch block (QRS ≥ 140 ms in men, ≥130 ms in women), and baseline PR interval ≤200 ms. In total, 3620 patients were randomized, including 1569 women (43.3%) approaching the actual proportion of women in the HF population. Women were older and more often New York Heart Association class III or IV than men (55.6% vs. 48.7%), had less frequent ischaemic cardiomyopathy (21.2% vs. 39.5%), and had a 5.1 ms shorter QRS duration than men. Women were more often depressed (18.5% vs. 9.7%), had a significantly lower Kansas City Cardiomyopathy Questionnaire score, and had differences in medication prescriptions.

Conclusions

AdaptResponse is the largest randomized CRT trial and enrolled more women than any other landmark CRT trial. Women differed from men with regard to baseline characteristics and quality of life. Whether these differences translate into clinical outcome differences will be examined further in the AdaptResponse trial.

Details

Title
Differences in clinical characteristics and reported quality of life of men and women undergoing cardiac resynchronization therapy
Author
Wilkoff, Bruce L 1 ; Birnie, David 2 ; Gold, Michael R 3 ; Hersi, Ahmad S 4 ; Jacobs, Sandra 5 ; Gerritse, Bart 5 ; Kusano, Kengo 6 ; Leclercq, Christophe 7 ; Mullens, Wilfried 8 ; Filippatos, Gerasimos 9 

 Cleveland Clinic, Cleveland, OH, USA 
 University of Ottawa Heart Institute, Ottawa, Ontario, Canada 
 Department of Cardiology, Medical University of South Carolina, Charleston, SC, USA 
 Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia 
 Medtronic Bakken Research Center, Maastricht, The Netherlands 
 National Cerebral and Cardiovascular Center, Osaka, Japan 
 Department of Cardiology, University of Rennes, Rennes, France 
 Department of Cardiology, Ziekenhuis Oost‐Limburg, Genk, Belgium and Hasselt University, Hasselt, Belgium 
 School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; School of Medicine, University of Cyprus, Nicosia, Cyprus 
Pages
2972-2982
Section
Original Research Articles
Publication year
2020
Publication date
Oct 2020
Publisher
John Wiley & Sons, Inc.
e-ISSN
20555822
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2447030170
Copyright
© 2020. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.