Abstract

[...]ACE2 was found to be expressed predominantly in tubular precursors of the kidney of the fetal case [Supplemental Figure 1, http://links.lww.com/CM9/A212]. High expression of the coronavirus receptors ACE2 and DPP4 in kidney tubule cells suggests that the kidney is at high risk of coronavirus infection. [...]there is an urgent need to develop specific drugs that target coronavirus receptors so as to prevent kidney damage. [...]kidney functions in patients infected with 2019-nCoV should be monitored frequently, particularly in patients with increased levels of plasma creatinine.

Details

Title
Single-cell RNA sequencing data suggest a role for angiotensin-converting enzyme 2 in kidney impairment in patients infected with 2019-novel coronavirus
Author
Yi-Yao, Deng; Zheng, Ying; Guang-Yan, Cai; Xiang-Mei, Chen; Quan, Hong
Pages
1129-1131
Section
Rapid Report
Publication year
2020
Publication date
May 2020
Publisher
Lippincott Williams & Wilkins Ovid Technologies
ISSN
03666999
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2459358622
Copyright
Copyright © 2020 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.