Abstract

Multifunctional lanthanide-based upconversion nanoparticles (UCNPs), which feature efficiently convert low-energy photons into high-energy photons, have attracted considerable attention in the domain of materials science and biomedical applications. Due to their unique photophysical properties, including light-emitting stability, excellent upconversion luminescence efficiency, low autofluorescence, and high detection sensitivity, and high penetration depth in samples, UCNPs have been widely applied in biomedical applications, such as biosensing, imaging and theranostics. In this review, we briefly introduced the major components of UCNPs and the luminescence mechanism. Then, we compared several common design synthesis strategies and presented their advantages and disadvantages. Several examples of the functionalization of UCNPs were given. Next, we detailed their biological applications in bioimaging and disease treatment, particularly drug delivery and photodynamic therapy, including antibacterial photodynamic therapy. Finally, the future practical applications in materials science and biomedical fields, as well as the remaining challenges to UCNPs application, were described. This review provides useful practical information and insights for the research on and application of UCNPs in the field of cancer.

Details

Title
Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment
Author
Liang, Gaofeng; Wang, Haojie; Shi, Hao; Wang, Haitao; Zhu, Mengxi; Jing, Aihua; Li, Jinghua; Li, Guangda
Pages
1-22
Section
Review
Publication year
2020
Publication date
2020
Publisher
BioMed Central
e-ISSN
14773155
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2462121513
Copyright
© 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.