Abstract

Asthma is a chronic heterogeneous illness of the lower airway with an inflammatory basis, developing from hyperresponsiveness and bronchial obstruction. One of the more unfavourable processes occurring in the airway are the long-term changes of the respiratory tract known as remodelling, resulting in complete irreversible obstruction. Bone morphogenetic protein (BMP) is a member of the Transforming Growth Factor beta (TGF-b) superfamily, which regulates processes in embryonic and post-embryonic development. The role played by BMP is regulation of degradation and remodelling of the extracellular matrix, which is one of the elements involved in the reconstruction of the structure of the bronchi in severe asthma. This paper presents the antagonistic properties of BMP against TGF-b, anti-inflammatory and counteracting fibrosis in the respiratory tract. The current state of knowledge indicates that this group of cytokines are potential new markers of remodelling in severe asthma, and further studies on their therapeutic value are necessary.

Details

Title
Selected bone morphogenetic proteins — the possibility of their use in the diagnostics and therapy of severe asthma
Author
Koćwin, Marcelina 1 ; Jonakowski, Mateusz 2 ; Przemęcka, Marcelina 2 ; Panek, Michał 2 ; Kuna, Piotr 2 

 Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz. [email protected] 
 Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 22 Kopcinskiego St., 90-153, Lodz, Poland 
First page
109
End page
115
Publication year
2017
Publication date
2017
Publisher
MDPI AG
ISSN
24514934
e-ISSN
25436031
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2464191578
Copyright
© 2017. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.