An evaluation of visfatin levels in obese subjects

Abstract

INTRODUCTION: Visfatin is a protein secreted by adipose tissue, which shows insulin mimetic properties. The role of visfatin in the development
of obesity, diabetes mellitus, and metabolic syndrome continues to raise controversy. The aim of the study was to evaluate visfatin
levels and to attempt to establish the relationship between visfatin and selected anthropometric and biochemical parameters in obese
individuals.

MATERIAL AND METHODS: The study included 68 obese subjects (15 men and 53 women) aged 37.8 ± 13.2 years with body mass index (BMI)
values of 39.4 ± 6.4 kg/m² without a previous diagnosis of abnormal glucose metabolism. The control group comprised 30 healthy nonobese
volunteers (6 men and 24 women) with normal glucose metabolism, aged 38.2 ± 14.9 years with BMI values of 22.8 ± 3.0 kg/m².

RESULTS: We found significantly higher visfatin levels in the obese subjects compared to the control group (median visfatin level of 39.6 v.
17.3 ng/ml, p = 0.0006). In the obese group there was a statistically significant negative correlation between visfatin levels and age (r = -0.26,
p = 0.034), waist-to-hip ratio (WHR) (r = -0.28, p = 0.031) and glycated haemoglobin (HbA1c) (r = -0.36, p = 0.0037). No statistically significant
correlations were found between visfatin levels and the remaining parameters under study. In the control group, visfatin levels did
not show any significant correlation with any of the parameters under study.

CONCLUSIONS: We found elevated levels of visfatin in obese subjects, which did not correlate with the majority of anthropometric parameters
with the exception of WHR (negative correlation). This correlation may suggest that elevated visfatin levels are associated with the
distribution of adipose tissue characteristic of gynoid rather than visceral obesity. In the group of obese subjects, visfatin levels decreased
with age and glycated haemoglobin levels.

(Pol J Endocrinol 2010; 61 (2): 169-173)