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1. Introduction
Zinc is an important micronutrient in the human body and it plays various biochemical roles characterized by catalytic, structural and regulatory functions [1]. Zinc deficiency can cause ailments in all age groups such as poor growth, compromised immune system, cognitive impairment, delayed sexual maturation and poor pregnancy outcomes [2]. Zinc deficiency is a global challenge, and more than 20% of children and women are estimated to be zinc deficient [3]. Although many countries lack national-level data on population zinc status, some countries such as Malawi conduct a periodic National Micronutrient Survey (MNS) in which biomarkers of zinc status are analysed.
Three main indicators (plasma/serum zinc concentration, dietary data and stunting) are recommended for use in the assessment of population-level zinc status [1]. Serum zinc is a biochemical indicator and it reflects individual zinc status to estimate zinc deficiency, compared to the other two indicators, which only predict the risk [2,4,5]. Despite this recommendation, serum zinc concentration (SZC) has limitations as a biomarker for zinc assessment, because it is affected by many factors such as inflammation, circadian variation and fasting status [2,6,7]. It is, nevertheless, the most commonly used indicator for population zinc status assessment; it was recently used in the Malawi MNS to assess zinc status of a nationally representative sample of men, women of reproductive age (WRA), school-age children (SAC), and pre-school children (PSC) [8]. Results from this survey indicated a zinc deficiency prevalence ranging from 60%–66% across these demographic groups. This prevalence is the highest recorded national prevalence in sub-Saharan Africa, and one of the highest globally [3]. However, the results were reported without adjusting for inflammation, which is an important confounder.
Inflammation induces a series of biochemical responses, which causes changes in serum and plasma concentration of acute phase reactants (APRs) in the body [9]. These APRs include nutrients such as zinc, which decrease in concentration, and ferritin, which increase in concentration. The SZC of an inflamed individual will thus be depressed below the actual value causing an artificial increase of the deficiency prevalence estimate. Several methods can be used to control for the effects of inflammation when reporting results of APR nutrients. The two most widely recommended methods use mathematical calculations to adjust the micronutrient concentrations [10,11,12,13,14,15,16,17,18]. These methods...
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