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© 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Commensal microbiota plays a critical role in the maintenance of human health. Microbes influence energy metabolism and nutrient absorption and help defend the host organism against pathogens. The composition of the gut microbiota is delicately balanced, and any alterations may lead to proinflammatory immune responses and initiation of disease processes, including cancer. Experimental evidence indicates that the human intestinal microbiota can influence tumour development and progression in the gastrointestinal tract by damaging DNA, activation of oncogenic signaling pathways, production of tumour-promoting metabolites, and suppression of the anti-tumour immune response. The aim of this article was to outline differences in human microbiota between healthy subjects and patients with gastrointestinal malignancies such as esophageal, stomach, liver, biliary tract, pancreas and colon inflammations, and cancers. A better understanding of microbiota changes in various gastrointestinal malignancies will enable a greater insight into the relationship between human microbiota composition and cancer development.

Details

Title
Microbiota Alterations in Gastrointestinal Cancers
First page
585
Publication year
2020
Publication date
2020
Publisher
MDPI AG
e-ISSN
20763417
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2468793358
Copyright
© 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.