Full text

Turn on search term navigation

© 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Stroke is the leading cause of serious long-term disability, significantly reducing mobility in almost half of affected patients aged 65 years and older. There are currently no proven neurorestorative treatments for chronic stroke. To address the complex problem of restoring function in ischemic brain tissue, stem cell transplantation-based approaches have emerged as promising restorative therapies. Aligning with the major cell types found within ischemic brain, stem cell based clinical trials for ischemic stroke have fallen under three broad cell lineages: hematopoietic, mesenchymal, and neural. In this review, we will discuss the scientific rationale for transplanting cells from each of these lineages and provide an overview of published and ongoing trials using this framework.

Details

Title
Revisiting Stem Cell-Based Clinical Trials for Ischemic Stroke
Author
He, Joy Q; Sussman, Eric S; Steinberg, Gary K
Section
Review ARTICLE
Publication year
2020
Publication date
Dec 14, 2020
Publisher
Frontiers Research Foundation
ISSN
16634365
e-ISSN
16634365
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2469886232
Copyright
© 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.