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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Moderate exercise combined with proper nutrition are considered protective factors against cardiovascular disease and musculoskeletal disorders. However, physical activity is known not only to have positive effects. In fact, the achievement of a good performance requires a very high oxygen consumption, which leads to the formation of oxygen free radicals, responsible for premature cell aging and diseases such as heart failure and muscle injury. In this scenario, a primary role is played by antioxidants, in particular by natural antioxidants that can be taken through the diet. Natural antioxidants are molecules capable of counteracting oxygen free radicals without causing cellular cytotoxicity. In recent years, therefore, research has conducted numerous studies on the identification of natural micronutrients, in order to prevent or mitigate oxidative stress induced by physical activity by helping to support conventional drug therapies against heart failure and muscle damage. The aim of this review is to have an overview of how controlled physical activity and a diet rich in antioxidants can represent a “natural cure” to prevent imbalances caused by free oxygen radicals in diseases such as heart failure and muscle damage. In particular, we will focus on sulfur-containing compounds that have the ability to protect the body from oxidative stress. We will mainly focus on six natural antioxidants: glutathione, taurine, lipoic acid, sulforaphane, garlic and methylsulfonylmethane.

Details

Title
Dietary Thiols: A Potential Supporting Strategy against Oxidative Stress in Heart Failure and Muscular Damage during Sports Activity
Author
Brancaccio, Mariarita 1   VIAFID ORCID Logo  ; Mennitti, Cristina 2   VIAFID ORCID Logo  ; Cesaro, Arturo 3   VIAFID ORCID Logo  ; Fimiani, Fabio 4 ; Moscarella, Elisabetta 3 ; Caiazza, Martina 4 ; Gragnano, Felice 3   VIAFID ORCID Logo  ; Ranieri, Annaluisa 5 ; Giovanni D’Alicandro 6 ; Tinto, Nadia 7 ; Mazzaccara, Cristina 2   VIAFID ORCID Logo  ; Lombardo, Barbara 7   VIAFID ORCID Logo  ; Pero, Raffaela 8 ; Limongelli, Giuseppe 9   VIAFID ORCID Logo  ; Frisso, Giulia 7 ; Calabrò, Paolo 3   VIAFID ORCID Logo  ; Scudiero, Olga 10   VIAFID ORCID Logo 

 Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy; [email protected] 
 Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy; [email protected] (C.M.); [email protected] (N.T.); [email protected] (C.M.); [email protected] (B.L.); [email protected] (R.P.) 
 Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, 81100 Naples, Italy; [email protected] (A.C.); [email protected] (E.M.); [email protected] (F.G.); [email protected] (G.L.); Division of Clinical Cardiology, A.O.R.N. “Sant’Anna e San Sebastiano”, 81100 Caserta, Italy 
 Inherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 81100 Naples, Italy; [email protected] (F.F.); [email protected] (M.C.) 
 Ceinge Biotecnologie Avanzate S. C. a R. L., 80131 Naples, Italy; [email protected] 
 Department of Neuroscience and Rehabilitation, Center of Sports Medicine and Disability, AORN, Santobono-Pausillipon, 80122 Naples, Italy; [email protected] 
 Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy; [email protected] (C.M.); [email protected] (N.T.); [email protected] (C.M.); [email protected] (B.L.); [email protected] (R.P.); Ceinge Biotecnologie Avanzate S. C. a R. L., 80131 Naples, Italy; [email protected] 
 Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy; [email protected] (C.M.); [email protected] (N.T.); [email protected] (C.M.); [email protected] (B.L.); [email protected] (R.P.); Task Force on Microbiome Studies, University of Naples Federico II, 80100 Naples, Italy 
 Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, 81100 Naples, Italy; [email protected] (A.C.); [email protected] (E.M.); [email protected] (F.G.); [email protected] (G.L.); Inherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 81100 Naples, Italy; [email protected] (F.F.); [email protected] (M.C.) 
10  Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy; [email protected] (C.M.); [email protected] (N.T.); [email protected] (C.M.); [email protected] (B.L.); [email protected] (R.P.); Ceinge Biotecnologie Avanzate S. C. a R. L., 80131 Naples, Italy; [email protected]; Task Force on Microbiome Studies, University of Naples Federico II, 80100 Naples, Italy 
First page
9424
Publication year
2020
Publication date
2020
Publisher
MDPI AG
ISSN
1661-7827
e-ISSN
1660-4601
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2471518919
Copyright
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.