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Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex chronic disease, rooted in multi-system dysfunctions characterized by unexplained debilitating fatigue. Post-exertional malaise (PEM), defined as the exacerbation of the patient's symptoms following minimal physical or mental stress, is a hallmark of ME/CFS. While multiple case definitions exist, there is currently no well-established biomarkers or laboratory tests to diagnose ME/CFS. Our study aimed to investigate circulating microRNA expression in severely ill ME/CFS patients before and after an innovative stress challenge that stimulates PEM. Our findings highlight the differential expression of eleven microRNAs associated with a physiological response to PEM. The present study uncovers specific microRNA expression signatures associated with ME/CFS in response to PEM induction and reports microRNA expression patterns associated to specific symptom severities. The identification of distinctive microRNA expression signatures for ME/CFS through a provocation challenge is essential for the elucidation of the ME/CFS pathophysiology, and lead to accurate diagnoses, prevention measures, and effective treatment options.
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Details
1 Sainte-Justine University Hospital Research Center, Viscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Office 2.17.027, Montreal, Canada (GRID:grid.411418.9) (ISNI:0000 0001 2173 6322); Université de Montréal, Molecular Biology PhD Program, Faculty of Graduate and Postdoctoral Studies, Montreal, Canada (GRID:grid.14848.31) (ISNI:0000 0001 2292 3357)
2 Sainte-Justine University Hospital Research Center, Viscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Office 2.17.027, Montreal, Canada (GRID:grid.411418.9) (ISNI:0000 0001 2173 6322); Université de Montréal, Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Montreal, Canada (GRID:grid.14848.31) (ISNI:0000 0001 2292 3357)
3 Sainte-Justine University Hospital Research Center, Patient-Partner, ICanCME Research Network, Montreal, Canada (GRID:grid.411418.9) (ISNI:0000 0001 2173 6322)
4 Sainte-Justine University Hospital Research Center, Viscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Office 2.17.027, Montreal, Canada (GRID:grid.411418.9) (ISNI:0000 0001 2173 6322)
5 University of Vermont, Department of Microbiology and Molecular Genetics, Burlington, USA (GRID:grid.59062.38) (ISNI:0000 0004 1936 7689)
6 Sainte-Justine University Hospital Research Center, Viscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Office 2.17.027, Montreal, Canada (GRID:grid.411418.9) (ISNI:0000 0001 2173 6322); Université de Montréal, Molecular Biology PhD Program, Faculty of Graduate and Postdoctoral Studies, Montreal, Canada (GRID:grid.14848.31) (ISNI:0000 0001 2292 3357); Université de Montréal, Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Montreal, Canada (GRID:grid.14848.31) (ISNI:0000 0001 2292 3357); Université de Montréal, Department of Stomatology, Faculty of Dentistry, Montreal, Canada (GRID:grid.14848.31) (ISNI:0000 0001 2292 3357)