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© 2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Abbreviations ACLF acute‐on‐chronic liver failure ALT alanine aminotransferase APRI aspartate aminotransferase to platelet ratio index ARFI acoustic radiation force impulse AST aspartate aminotransferase AUROC area under the receiver operating characteristic curve cHBV chronic hepatitis B virus cHCV chronic hepatitis C virus CI confidence interval DAA direct‐acting antiviral FIB‐4 Fibrosis‐4 GT genotype HBV hepatitis B virus HCC hepatocellular carcinoma HCV hepatitis C virus HR hazard ratio LRE liver‐related event PC platelet count pSWE point shear‐wave elastography TE transient elastography Chronic viral hepatitis is a serious global health burden, accounting for approximately 1.46 million deaths worldwide. ( 1) More than 90% of these deaths are due to the sequelae of infections with hepatitis B virus (HBV) and hepatitis C virus (HCV), including cirrhosis, liver failure, and hepatocellular carcinoma (HCC). ( 5) Despite the success of antiviral treatments, a substantial proportion of patients already have advanced liver disease at the time of diagnosis and are at risk of developing liver‐related complications despite permanent clearance of the virus from the bloodstream. [...]early identification of patients at risk is of major clinical importance, and management and follow‐up of these patients has become a core component of our daily clinical practice. For assessment of independent predictors of survival, a multivariate Cox proportional‐hazards regression model with forward stepwise (likelihood ratio) entry was applied. Because the number of LREs was small among patients with HBV, no regression model was applied.

Details

Title
Point Shear‐Wave Elastography Using Acoustic Radiation Force Impulse Imaging for the Prediction of Liver‐Related Events in Patients With Chronic Viral Hepatitis
Author
Lisa Hernandez Sampere 1 ; Vermehren, Johannes 1 ; Mücke, Victoria T 1   VIAFID ORCID Logo  ; Graf, Christiana 1 ; Kai‐Henrik Peiffer 1 ; Dultz, Georg 1 ; Zeuzem, Stefan 1 ; Waidmann, Oliver 1 ; Filmann, Natalie 2 ; Bojunga, Joerg 1 ; Sarrazin, Christoph 3 ; Mireen Friedrich‐Rust 1 ; Mücke, Marcus M 1   VIAFID ORCID Logo 

 Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany 
 Institute of Biostatistics and Mathematical Modeling, Goethe University, Frankfurt am Main, Germany 
 Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany; St. Josefs‐Hospital, Wiesbaden, Germany 
Pages
112-121
Section
Original Articles
Publication year
2021
Publication date
Jan 2021
Publisher
Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
e-ISSN
2471254X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2475794323
Copyright
© 2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.