It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Epstein–Barr virus-associated diseases are important global health concerns. As a group I carcinogen, EBV accounts for 1.5% of human malignances, including both epithelial- and lymphatic-originated tumors. Moreover, EBV plays an etiological and pathogenic role in a number of non-neoplastic diseases, and is even involved in multiple autoimmune diseases (SADs). In this review, we summarize and discuss some recent exciting discoveries in EBV research area, which including DNA methylation alterations, metabolic reprogramming, the changes of mitochondria and ubiquitin-proteasome system (UPS), oxidative stress and EBV lytic reactivation, variations in non-coding RNA (ncRNA), radiochemotherapy and immunotherapy. Understanding and learning from this advancement will further confirm the far-reaching and future value of therapeutic strategies in EBV-associated diseases.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, China; Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China (GRID:grid.216417.7) (ISNI:0000 0001 0379 7164); Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, China (GRID:grid.216417.7); Research Center for Technologies of Nucleic Acid-Based Diagnostics and Therapeutics Hunan Province, Changsha, China (GRID:grid.216417.7); Molecular Imaging Research Center of Central South University, Changsha, China (GRID:grid.216417.7) (ISNI:0000 0001 0379 7164); National Joint Engineering Research Center for Genetic Diagnostics of Infectious Diseases and Cancer, Changsha, China (GRID:grid.216417.7); Department of Radiology, Xiangya Hospital, Central South University, Changsha, China (GRID:grid.216417.7)
2 Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, China (GRID:grid.216417.7); Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China (GRID:grid.216417.7) (ISNI:0000 0001 0379 7164); Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, China (GRID:grid.216417.7)
3 Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, China (GRID:grid.216417.7); Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, China (GRID:grid.216417.7) (ISNI:0000 0001 0379 7164); Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, China (GRID:grid.216417.7); Molecular Imaging Research Center of Central South University, Changsha, China (GRID:grid.216417.7) (ISNI:0000 0001 0379 7164)
4 Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, China (GRID:grid.216417.7)
5 Department of Radiology, Xiangya Hospital, Central South University, Changsha, China (GRID:grid.216417.7)
6 The Hormel Institute, University of Minnesota, Austin, USA (GRID:grid.17635.36) (ISNI:0000000419368657)