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Abstract
Recently, waist to hip ratio (WHR) has been reported to be a better indicator of predicting cardiovascular outcomes than body mass index (BMI). We evaluated the effects of pre or post-transplant changes of WHR or BMI on the new onset cardiovascular diseases (CVD) in recipients of kidney transplantation (KT). A total of 572 patients were enrolled from a multicenter observational cohort (KNOW-KT). Measurement of WHR and BMI was done at pre-KT, first and last visit year after KT, and the changes of these parameters and their effect on the incident CVD were analyzed. During the median follow up period of 32.73 ± 15.26 months, the new onset CVD developed in 31 out of 572 patients. The older age, diabetes mellitus and increase of WHR from pre KT or previous follow up year were found to be independent factors predicting the new onset CVD in these patients. However, baseline BMI, WHR prior to KT did not predict the incident CVD. The new metabolic burden, presented as increase of WHR in KT patients has a critical impact on the development of new onset CVD. Strategies to prevent the metabolic burden after KT might improve cardiovascular outcomes and patient’s survival.
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Details
1 Korea University College of Medicine, Department of Transplantation and Vascular Surgery, Seoul, Korea (GRID:grid.222754.4) (ISNI:0000 0001 0840 2678)
2 Korea University College of Medicine, Department of Biostatistics, Seoul, Korea (GRID:grid.222754.4) (ISNI:0000 0001 0840 2678)
3 Korea University College of Medicine, Department of Internal Medicine, Seoul, Korea (GRID:grid.222754.4) (ISNI:0000 0001 0840 2678)
4 Sungkyunkwan University, Department of Surgery, Seoul Samsung Medical Center, Seoul, Korea (GRID:grid.264381.a) (ISNI:0000 0001 2181 989X)
5 Yonsei University College of Medicine, Department of Surgery, Seoul, Korea (GRID:grid.15444.30) (ISNI:0000 0004 0470 5454)
6 Gachon University Gil Hospital, Department of Internal Medicine, Incheon, Korea (GRID:grid.411652.5)
7 Keimyung University School of Medicine, Department of Internal Medicine, Daegu, Korea (GRID:grid.412091.f) (ISNI:0000 0001 0669 3109)
8 Kyungpook National University Hospital, Department of Internal Medicine, Daegu, Korea (GRID:grid.411235.0) (ISNI:0000 0004 0647 192X)
9 Chonbuk National University Hospital, Department of Internal Medicine, Jeonju, Korea (GRID:grid.411551.5) (ISNI:0000 0004 0647 1516)
10 Seoul National University Hospital, Transplantation Center, Seoul, Korea (GRID:grid.412484.f) (ISNI:0000 0001 0302 820X)