Carboxyhemoglobin, a reliable diagnosis biomarker for hemolysis in intensive care unit: a retrospective study

Abstract

During hemolysis, free hemoglobin released by red blood cells is catabolized by heme-oxygenase 1, leading to formation of iron, biliverdin and carbon monoxide [2]. Haptoglobin is another biomarker for hemolysis, but its level may change in several critical conditions including sepsis or red blood cell transfusion [6]. Carboxyhemoglobin has to be analyzed after evaluation of confounding factors that potentially increase (heavy smoker, sepsis, carbon monoxide chronic sub-intoxication) or decrease (hyperoxia) its levels. Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.