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© 2020 Carter et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Past emphasis has been on various components of innate and adaptive immunity of the host with more recent focus being given to individual cytokines and a number of programmed cell death pathways [16]. In an attempt to overcome this obstacle, we employed NanoString nCounter technology which allows for the direct measurement of immune response gene expression levels without amplification during the onset and progression of retinitis within MCMV-infected eyes of mice with MAIDS. Results Hierarchical clustering analysis of 561 immune response gene transcripts within MCMV-infected eyes of healthy mice, MAIDS-4 mice, and MAIDS-10 mice Several prior investigations by us have confirmed major differences in the susceptibility to development of full-thickness retinal necrosis when comparing the MCMV-infected eyes of healthy mice with the MCMV-infected eyes of mice at different stages of retrovirus-induced immunosuppression [13,17]. [...]distinctly different expression patterns for individual immune response genes were observed within the MCMV-infected eyes of MAIDS-10 mice following development of full-thickness retinal necrosis but not within MCMV-infected eyes of MAIDS-4 mice resistant to full-thickness retinal necrosis development.

Details

Title
Transcriptional analysis of immune response genes during pathogenesis of cytomegalovirus retinitis in mice with murine acquired immunodeficiency syndrome
Author
Carter, Jessica J  VIAFID ORCID Logo  ; Gardner, Jesse M  VIAFID ORCID Logo  ; Poling, Brent P; Welch, Madeline M  VIAFID ORCID Logo  ; Judee Grace E. Nemeno  VIAFID ORCID Logo  ; Houghton, John E; Dix, Richard D  VIAFID ORCID Logo 
First page
e1009032
Section
Research Article
Publication year
2020
Publication date
Nov 2020
Publisher
Public Library of Science
ISSN
15537366
e-ISSN
15537374
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2479469202
Copyright
© 2020 Carter et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.