Abstract
Flow cytometry of the bone marrow aspirate found no clonal lymphoproliferation. [...]the patient was diagnosed EBV-associated hemophagocytic lymphohistiocytosis (HLH) due to fever, pancytopenia, elevated triglyceride, liver dysfunction, coagulopathy, and obviously elevated serum ferritin and sIL-2R. Previous researches into the basic pathoetiology of systemic inflammatory disorders have led to the introduction of next-generation biologic treatments including kinase inhibitors and targeted interleukin-18 or IFN-γ blockade into systemic juvenile idiopathic arthritis and macrophage activation syndrome. [2] On the other hand, IFN-α is known to suppress viral DNA replication by affecting its basal promoter activation process, it is rarely used in CAEBV patients.
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