Abstract
[18] LAPTM4B down-regulation also down-regulated several cancer-related proteins in cervical cancer cells, including VEGF, cyclin-dependent kinase 12, hypoxia inducible factor 1 subunit alpha, MMP-2, and MMP-9 and dramatically blocked VEGF expression. [27] Thus, LAPTM4B is involved in the PI3K/AKT signaling pathway, and plays a fundamental role in the activation of PI3K/AKT signaling. [...]the PI3K/AKT signaling pathway, in combination with LAPTM4B, may represent a target for the amelioration of multidrug resistance in cancer therapy. Promisingly, LAPTM4B may facilitate angiogenesis by boosting a crucial growth factor involved in cancer. [...]the LAPTM4B-VEGF axis may be a potential candidate target for cancer therapy.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China
2 Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China