Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms. Dyskinesia and motor fluctuations are complications of PD medications. An objective measure of on/off time with/without dyskinesia has been sought for some time because it would facilitate the titration of medications. The objective of the dataset herein presented is to assess if wearable sensor data can be used to generate accurate estimates of limb-specific symptom severity. Nineteen subjects with PD experiencing motor fluctuations were asked to wear a total of five wearable sensors on both forearms and shanks, as well as on the lower back. Accelerometer data was collected for four days, including two laboratory visits lasting 3 to 4 hours each while the remainder of the time was spent at home and in the community. During the laboratory visits, subjects performed a battery of motor tasks while clinicians rated limb-specific symptom severity. At home, subjects were instructed to use a smartphone app that guided the periodic performance of a set of motor tasks.

Measurement(s)

body movement coordination trait • Movement Disorder Society Unified Parkinson’s Disease Rating Scale Questionnaire • Medication • motor coordination/balance trait • sleep pattern • MDS-UPDRS Tasks and Simulated Activities of Daily Living (in-clinic) • Activity of Daily Living

Technology Type(s)

Accelerometer • body movement/behavior method • Clinical Observation • smartphone • Subject Diary

Factor Type(s)

age of patient • gender of patient • timing of medication intake

Sample Characteristic - Organism

Homo sapiens

Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare.13574279

Details

Title
Limb and trunk accelerometer data collected with wearable sensors from subjects with Parkinson’s disease
Author
Vergara-Diaz, Gloria 1 ; Daneault Jean-Francois 2 ; Parisi Federico 1 ; Chen, Admati 3 ; Alfonso, Christina 4 ; Bertoli Matilde 1 ; Bonizzoni Edoardo 1 ; Carvalho, Gabriela Ferreira 1 ; Costante Gianluca 1 ; Fabara Eric Eduardo 1 ; Fixler Naama 3 ; Golabchi, Fatemah Noushin 1 ; Growdon, John 5 ; Sapienza Stefano 1 ; Snyder, Phil 6   VIAFID ORCID Logo  ; Shpigelman Shahar 7 ; Sudarsky Lewis 8 ; Daeschler Margaret 9 ; Bataille, Lauren 9 ; Sieberts, Solveig K 6   VIAFID ORCID Logo  ; Larsson, Omberg 6 ; Moore, Steven 10   VIAFID ORCID Logo  ; Bonato Paolo 11   VIAFID ORCID Logo 

 Spaulding Rehabilitation Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, USA (GRID:grid.416228.b) (ISNI:0000 0004 0451 8771) 
 Spaulding Rehabilitation Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, USA (GRID:grid.416228.b) (ISNI:0000 0004 0451 8771); Rutgers University, Department of Rehabilitation and Movement Sciences, Newark, USA (GRID:grid.430387.b) (ISNI:0000 0004 1936 8796) 
 Intel Corporation, IT Advanced Analytics, HaMerkaz, Israel (GRID:grid.416228.b) 
 Icahn School of Medicine at Mount Sinai, Department of Neurology, New York, USA (GRID:grid.59734.3c) (ISNI:0000 0001 0670 2351) 
 Massachusetts General Hospital, Department of Neurology, Harvard Medical School, Boston, USA (GRID:grid.32224.35) (ISNI:0000 0004 0386 9924) 
 Sage Bionetworks, Seattle, USA (GRID:grid.430406.5) (ISNI:0000 0004 6023 5303) 
 Intel Corporation, IT Advanced Analytics, HaMerkaz, Israel (GRID:grid.430406.5) 
 Brigham and Women’s Hospital, Department of Neurology, Harvard Medical School, Boston, USA (GRID:grid.62560.37) (ISNI:0000 0004 0378 8294) 
 Michael J Fox Foundation, New York, USA (GRID:grid.430781.9) (ISNI:0000 0004 5907 0388) 
10  Icahn School of Medicine at Mount Sinai, Department of Neurology, New York, USA (GRID:grid.59734.3c) (ISNI:0000 0001 0670 2351); Central Queensland University, School of Engineering and Technology, Rockhampton, Australia (GRID:grid.1023.0) (ISNI:0000 0001 2193 0854) 
11  Spaulding Rehabilitation Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, USA (GRID:grid.416228.b) (ISNI:0000 0004 0451 8771); Harvard University, Wyss Institute for Biologically Inspired Engineering, Cambridge, USA (GRID:grid.38142.3c) (ISNI:000000041936754X) 
Publication year
2021
Publication date
2021
Publisher
Nature Publishing Group
e-ISSN
20524463
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2486620989
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.