Abstract

Resting-state EEG microstates are brief (50–100 ms) periods, in which the spatial configuration of scalp global field power remains quasi-stable before rapidly shifting to another configuration. Changes in microstate parameters have been described in patients with psychotic disorders. These changes have also been observed in individuals with a clinical or genetic high risk, suggesting potential usefulness of EEG microstates as a biomarker for psychotic disorders. The present study aimed to investigate the potential of EEG microstates as biomarkers for psychotic disorders and future transition to psychosis in patients at ultra-high-risk (UHR). We used 19-channel clinical EEG recordings and orthogonal contrasts to compare temporal parameters of four normative microstate classes (A–D) between patients with first-episode psychosis (FEP; n = 29), UHR patients with (UHR-T; n = 20) and without (UHR-NT; n = 34) later transition to psychosis, and healthy controls (HC; n = 25). Microstate A was increased in patients (FEP & UHR-T & UHR-NT) compared to HC, suggesting an unspecific state biomarker of general psychopathology. Microstate B displayed a decrease in FEP compared to both UHR patient groups, and thus may represent a state biomarker specific to psychotic illness progression. Microstate D was significantly decreased in UHR-T compared to UHR-NT, suggesting its potential as a selective biomarker of future transition in UHR patients.

Details

Title
EEG microstates as biomarker for psychosis in ultra-high-risk patients
Author
de Bock Renate 1   VIAFID ORCID Logo  ; Mackintosh, Amatya J 1 ; Maier Franziska 2 ; Borgwardt, Stefan 3 ; Riecher-Rössler Anita 4 ; Andreou, Christina 5   VIAFID ORCID Logo 

1  University of Basel, University Psychiatric Clinics (UPK) Basel, Basel, Switzerland (GRID:grid.6612.3) (ISNI:0000 0004 1937 0642); University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, Basel, Switzerland (GRID:grid.6612.3) (ISNI:0000 0004 1937 0642) 
2  University of Basel, University Psychiatric Clinics (UPK) Basel, Basel, Switzerland (GRID:grid.6612.3) (ISNI:0000 0004 1937 0642) 
3  University of Basel, University Psychiatric Clinics (UPK) Basel, Basel, Switzerland (GRID:grid.6612.3) (ISNI:0000 0004 1937 0642); University of Lübeck, Department of Psychiatry and Psychotherapy, Lübeck, Germany (GRID:grid.4562.5) (ISNI:0000 0001 0057 2672) 
4  University of Basel, Faculty of Medicine, Basel, Switzerland (GRID:grid.6612.3) (ISNI:0000 0004 1937 0642) 
5  University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, Basel, Switzerland (GRID:grid.6612.3) (ISNI:0000 0004 1937 0642); University of Lübeck, Department of Psychiatry and Psychotherapy, Lübeck, Germany (GRID:grid.4562.5) (ISNI:0000 0001 0057 2672) 
Publication year
2020
Publication date
2020
Publisher
Nature Publishing Group
e-ISSN
21583188
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41398-020-00963-7
ProQuest document ID
2487257890
Copyright
© The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.