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Abstract
The morbidity and mortality of cryptococcal meningoencephalitis (CM) in previously healthy, HIV-negative individuals is increasingly recognized. We administered a healthcare associated quality of life (QOL) survey to the largest longitudinally followed cohort of these patients in the United States. We identified moderate or severe self-reported impairment in at least one QOL domain in 61% of subjects at least one year following diagnosis. Self-reported cognitive impairment was noted in 52% and sleep disturbance was noted in 55%. This is the first comprehensive study of cross-sectional long-term QOL in previously healthy patients following cryptococcal infection.
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Details
1 National Institutes of Health, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, USA (GRID:grid.94365.3d) (ISNI:0000 0001 2297 5165)
2 National Institutes of Health, National Institute of Mental Health, Bethesda, USA (GRID:grid.94365.3d) (ISNI:0000 0001 2297 5165)
3 Frederick National Laboratory for Cancer Research, Clinical Research Directorate, Frederick, USA (GRID:grid.418021.e) (ISNI:0000 0004 0535 8394)
4 National Institutes of Health, Biostatistics Research Branch, National Institutes of Allergy and Infectious Diseases, Bethesda, USA (GRID:grid.94365.3d) (ISNI:0000 0001 2297 5165)
5 Johns Hopkins University School of Medicine, Baltimore, USA (GRID:grid.21107.35) (ISNI:0000 0001 2171 9311)